##American Diabetes Association. 1997. Report of the diagnosis and classification of diabetes mellitus. Diabetes Care, 20:1183-201.##Szkudelski T, Kandulska K, Okulicz M. 1998. Alloxan in vivo does not only exert deleterious effects on pancreaticcells.Physiol Res, 47: 343-346##Lenzen S, Munday R. 1991. Thiol-group reactivity, hydrophili- city and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin. Biochem Pharmacol, 42:1385-1391.##Dunn JS, Sheehan HL, Mclethie NGB. 1943. Necrosis of islets of Langerhans produced experimentally. Lancet, 1: 484-487.##Eizirik DL, Pipeleers DG, Ling Z. 1994. Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.ProcNatlAcadSci, 91: 9253-9256.##Katsumata K, Katsumata Y, Ozawa T, Katsumata K, Jr. 1993. Potentiating effects of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetes in rats.HormMetab Res, 25: 125-126.##Bansal R, Ahmad N, Kidwai JR. 1980. Alloxan-glucose interaction: effect of incorporation of 14C-leucine into pancreatic islets of rats.ActaDiabetolLat, 17: 135-143.##Gorus FK, Malaisse WJ, Pipeleers DG. 1982. Selective uptake of alloxan by pancreatic B-cells. Biochem J, 208:513-515.##Miwa I, Hara H, Matsunaga H, Okuda J. 1984. Inhibition of glucokinase in hepatocytes by alloxan. BiochemInt, 9:595-602.##Winterbourn CC, Munday R. 1989. Glutathione-mediated redox cycling of alloxan. Mechanisms of superoxide dismutase inhibition and of metal-catalyzed OH. formation. BiochemPharmacol, 38:271-277.##Sakurai K, Ogiso T. 1991. Inhibitory effect of glutathione on the generation of hydroxyl radicals in the reaction system of glutathione-alloxan.Chem Pharm Bull, 39: 737-742.##Munday R. 1988. Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species. BiochemPharmacol, 37:409-413.##Lenzen S, Panten U.1998. Alloxan: history and mechanism of action. Diabetologia, 31:337-342.##Elsner M, Gurgul-Convey E, Lenzen S. 2006. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells. Free RadicBiol Med 41:825-834.##Tiedge M, Richter T, Lenzen S. 2000. Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase. Arch BiochemBiophys, 375:251-260.##Park BH, Rho HW, Park JW. 1995. Protective mechanism of glucose against alloxan-induced pancreatic beta-cell damage.BiochemBiophysResCommun, 210: 1-6.##Kim HR, Rho HW, Park JW. 1994. Role of Ca2+ in alloxan-induced pancreatic beta-cell damage.BiochimBiophysActa, 1227: 87-91.##Kodama T, Iwase M, Maki Y, Yoshinari M. 1993.New diabetes model induced by neonatal alloxantreatment in rats. Diabetes Res ClinPract, 20:183-9.##Axler DA. 1982. Stability of the diabetogenic activity of streptozotocin. IRCS Med Sci, 10:157-158.##Ganda OP, Rossi AA, Like AA. 1976. Studies on streptozotocin diabetes. Diabetes, 25: 595-603.##Portha B, Picon L, Rosselin G. 1979. Chemical diabetes in the adult rats as the spontaneous evolution of neonatal diabetes.Diabetologia, 17: 371-377.##Larsen MO, Wilken M, Gotfredsen CF. 2002. Mild streptozotocin diabetes in the Gottingen minipig. A novel model of moderate insulin deficiency and diabetes.Am J PhysiolEndocrinolMetab, 282: E1342-51.##Thulesen J, Orskov C, Holst JJ, Poulsen SS. 1997. Short-term insulin treatment prevents the diabetogenic action of streptozotocin in rats. Endocrinology, 138: 62-68.##Elsner M, Guldbakke B, Tiedge M, Munday R. 2000. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.Diabetologia, 43: 1528-1533.##Kroncke KD, Fehsel K, Sommer A, Rodriguez ML. 1995. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage.BiolChem Hoppe-Seyler, 376: 179-185.##Nukatsuka M, Sakurai H, Yoshimura Y. 1988. Enhancement by streptozotocin of O2" radical generation by the xanthine oxidase system of pancreatic betacells.FEBSLett, 239: 295-298.##Pieper AA, Brat DJ, Krug DK. 1999. Poly (ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.ProcNatlAcadSci USA, 96: 3059-3064.##Dulin WE, Wyse BM. 1969. Reversal of streptozotocin diabetes with nicotinamide. ProcSocExpBiol Med, 130:992-994.##Burkart V, Wang ZQ, Radons J, Heller B. 1999. Mice lacking the poly (ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med, 5:314-319.##Mythili MD, Vyas R, Akila G, Gunasekaran S. 2004. Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microsc Res Tech, 63:274-281.##Ledoux SP, Hall CR, Forbes PM. 1988. Mechanismsof nicotinamide and thymidine protection from alloxan and streptozotocin toxicity. Diabetes, 37: 1015-1019.##Szkudelski T. 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res, 50:537-546.##
)