عنوان مقاله [English]
Background: The purpose of the present study was to investigate the effect of SNL on the expression of Tweak and Fn14 in the EDL muscle of Wistar rats after HIT training.
Methods: For this purpose, 24 male rats were divided into 2 groups of control (C) (n=12) and training (HIT) (n=12). After one-week familiarization, training group participate in four HIT training. Then,they were randomly assigned to HIT (n=6) and HIT-SNL (n=6) groups. At the same time, the control group was divided into two groups: control (C) (n=6) and SNL (C-SNL) (n=6). 4 weeks after the SNL, wistar rats were sacrificed and soleuse muscle exetracted.Then expressions of Tweak and Fn14 measured with Real time PCR technique.
Results: The results showed that inactivity by SNL has a significant effect on the expression of Tweak and Fn14 genes (P=0.000and P=0.002, respectively). Also, performed before SNL reduced the expression of Tweak and Fn14 (P=0.0001 and P=0.001 respectively). In addition,the findings indicated that SNL had a significant effect on the weight of Soleuse muscle mass/ tibia length (P=0.01). On the other hand, HIT training before SNL significantly increased weight of Soleuse muscle mass/ tibia length (P=0.03).
Conclusion: Therefore, the decrease in activity by SNL is associated with increased in expression of Tweak and Fn14 genes, which may be involved in muscle mass changes. Performing HIT reduces the expression of these genes in EDL muscle. liekly, HIT training recuried fast twich muscles and then expression of atrophic genes is suppressed as a result of these training.