نوع مقاله: مقاله پژوهشی
نویسندگان
1 دانشجوی دکترای فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه اصفهان
2 استاد گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران
3 استاد گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 دانشیار گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background&Purpose: Parkinson’s disease is a neurodegenerative disorder that is characterized by impairment on behavioral, cognitive and biochemical. This study investigated the effect of endurance training after the 6-OHDA induction, on PGC-1α, FNDC5 and BDNF expression.
Methodology: In this study, Parkinson’s rats were made by 8𝜇g injection of 6-OHDA into the Medial Forebrain Bundle using stereotaxic. Experimental groups were: 1. Saline, 2. 6-OHDA, 3. Saline+training and 4. 6-OHDA+training (n=8). Training groups 2 weeks after surgery started 14 consecutive days treadmill running. 4 weeks after the induction with 6-OHDA/Saline, mRNA expression levels for PGC-1α, FNDC5 and BDNF were measured through one way ANOVA in the striatum of rats.
Results: It was found that exposure to the 6-OHDA (6-OHDA group), resulted in increasing in the apomorphine-induced rotational asymmetry and significant decrease in mRNAs expression of PGC-1α/FNDC5/BDNF signalling pathway. However, endurance exercise in 6-OHDA+training group reduces these disorders, significantly (p≤0/05).
Conclusion: It seems that the endurance training can reduce behavioral and physiological disorders in Parkinson’s disease
کلیدواژهها [English]