تاثیر مصرف آلفا لیپوئیک اسید (ALA) بر شاخص های منتخب کوفتگی تاخیری پس از یک جلسه فعالیت برونگرای شدید

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

2 استاد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

3 دانشیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد اردبیل، دانشگاه آزاد اسلامی، اردبیل، ایران

چکیده

مقدمه و هدف: آلفا لیپوئیک اسید (ALA) یک مکمل غذایی است که آثار آنتی اکسیدانی و ضدالتهابی دارد. هدف از تحقیق حاضر تعیین تاثیر مصرف هشت روزه ALA قبل از یک جلسه فعالیت برونگرای شدید بر شاخص های منتخب مرتبط با کوفتگی تاخیری می باشد.
مواد و روش ها: ده مرد سالم جوان به صورت تصادفی، دوسویه کور و با گروه کنترل و با طرح متقاطع در این تحقیق شرکت کردند، تا تاثیر هشت روز مصرف ALA (600 میلی گرم در روز) و یا دارونما (600 میلی گرم در روز گلوکز) متعاقب یک جلسه تمرین برونگرای غیر آشنا بررسی شود.نمونه های خونی در وضعیت پایه، هشت روز پس از مصرف مکمل، بلافاصله، 24، 48 و 72 ساعت پس از فعالیت اخذ گردید. ظرفیت آنتی اکسیدانی تام (TAC)، کراتین کیناز ((CK، شاخص درد بصری ((VAS، ادم دور ران ها و دامنه حرکتی زانوها (ROM) در هر دو دوره مورد اندازه گیری قرار گرفتند.
یافته ها: هشت روز پس از مصرف مکمل، TACدر گروه ALA به طور معنی داری افزایش یافت (p=0.023). شاخص آسیب عضلانی (CK)، بلافاصله، 24 و 48 ساعت پس از فعالیت در هر دو گروه نسبت به قبل از فعالیت افزایش معنی دار نشان داد، اما 72 ساعت پس از فعالیت فقط در گروه دارونما افزایش یافت (p <0.05). درد عضلانی (VAS)،24، 48 و 72 ساعت پس از فعالیت در گروه دارونما  هم نسبت به قبل از فعالیت و هم نسبت به گروه ALA افزایش معنی دار نشان داد (p <0.05). تغییر معنی دار درون گروهی یا بین گروهی در ارتباط با ROM مشاهده نشد (p>0.05).
بحث و نتیجه گیری: به نظر می رسد مصرف هشت روزه مکمل ALA قبل از فعالیت برونگرا توانسته است از طریق خواص آنتی اکسیدانی و ضدالتهابی خود باعث کاهش درد، آسیب عضلانی و التهاب شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of α-Lipoic Acid (ALA) Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS) After one Session Intensive Eccentric Exercise

نویسندگان [English]

  • Somayyeh Valizadeh 1
  • Marefat Siahkoohian 2
  • Babak Nakhostin-Roohi 3
1 1. Department of Physical Education &amp; Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
2 1. Department of Physical Education &amp; Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
چکیده [English]

Aim: The purpose of this study was to assess the effect of eight day α-Lipoic Acid (ALA) supplementation before intensive eccentric exercise on some selected markers of Delayed Onset Muscle Soreness (DOMS).
Method & Materials: Ten healthy young males voluntarily participated in a double-blind randomized- controlled crossover trial to estimate the effects of 8day ALA oral supplementation (600mg/day) (A group) versus placebo (600mg/day glucose) (P group) following an unaccustomed heavy eccentric exercise. Measurements were made at baseline, 8days after supplementation, immediately, 24, 48, and 72 hours after exercise comprising: (a) TAC (b) CK (c) limb pain (1–10 cm visual analogue scale; VAS), (d) edema of both thighs, and (e) ROM of both knees.
Results: TAC increased 8days after supplementation in A group compared with P group (p0.05). Limb pain was significantly more in P group than A group, 24, 48, and 72 hours after exercise (p Conclusion: The finding of this study suggests that 8day supplementation of ALA before intensive eccentric exercise may attenuate pain, muscle damage and inflammation via antioxidant and anti-inflammatory effects of ALA.

کلیدواژه‌ها [English]

  • Delayed Onset Muscle Soreness (DOMS)
  • Alpha Lipoic Acid (ALA)
  • Total Antioxidant Capacity (TAC)
  • Creatine Kinase (CK)
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