تازه های تحقیق
عنوان مقاله [English]
Background and Purpose: this study was conducted to assess and comparison of effects eight-weeks endurance training (ET) and resistance training (RT) and garlic extract supplementation on High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine in male wistar rats with metabolic syndrome.
Methodology: A total of 48 rats with metabolic syndrome (aged 12-wk, weight 331.94±13.67g) were randomly divided into 6 groups of 8 each: endurance training (ET), resistance training (RT), garlic extract supplementation (GE), endurance training with garlic extract supplementation (ET+GE), resistance training with garlic extract supplementation (RT+GE) and control (con). Exercise and dietary interventions for 8 weeks. After familiarization rats with metabolic syndrome, 8-weeks (3 session a week) in a exercise protocol (ET,RT) with and without GE (500 mg.kg-1.day-1).
Results: The results showed that hs-CRP in all groups except Group resistance + garlic is lower than the control group significantly (P˂0.05). Moreover, rang of The hs-CRP in the group of endurance training alone and enduance + garlic is lower than resistance+ garlic (P˂0.05). As well as, range of homocysteine in group of endurance alone, endurance+garlic and resistance garlic is lower compared to control group (P˂0.05). None of intervention was a significant effect on lipoprotein (a) compared to the control group (P>0.05).
Conclusion: Based on the findings of this study can be concluded that endurance training and resistance training with and without garlic extract can be effective in reducing inflammation and coronary artery disease. it would appear that the combination of garlic supplementation with endurance exercise is more helpful than the resistance exercise.
##Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. 1992. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 41:715-722.## Alexander CM. 2003. The coming of age of the metabolic syndrome. Diabetes care. 26(11):3180-3181.## National Cholesterol Education Program (NCEP). 2002. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 106:3143–3421.## Bizheh N, Jaafari M. 2011. The Effect of a Single Bout Circuit Resistance Exercise on Homocysteine, hs-CRP and Fibrinogen in Sedentary Middle Aged Men. Iran J Basic Med Sci. 14(6):568-573.##Hejazi M, Rashidlamir A, Jebbelli A, Nornematollahi S, Ghazavi M, Soltani M. 2013. The effects of 8 weeks’ aerobic exercise on levels of homocysteine, HS-CRP serum and plasma fibrinogen in type II diabetic women. Life Sci J. 10(1s):430-435.## Onat A, Ceyhan K, Başar O, Erer B, Toprak S, Sansoy V. 2002. Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels – a prospective and cross-sectional evaluation. Atherosclerosis. 165(2):285–292.## Tibana RA, Navalta J, Bottaro M, Vieira D, Tajra V, Silva Ade O, et al. 2013. Effects of eight weeks of resistance training on the risk factors of metabolic syndrome in overweight /obese women - “A Pilot Study”. Diabetol Metab Syndr. 28(1):11-15.## Williams MJ, Sutherland WH, McCormick MP. 2005. Aged Garlic Extract Improves Endothelial Function in Men with Coronary Artery Disease. Phytother Res. 19(4):314-319.## Wotherspoon F, Laight DW, Browne DL, Turner C, Meeking DR, Allard SE, et al. 2006. homocysteine, oxidative stress and endothelial function in patients with Type 1 diabetes mellitus and microalbuminuria. Diabet Med. 23(12):1350-1356.## Marcovina SM, Koschinsky ML. 2003. Evaluation of lipoprotein(a) as a prothrombotic factor: progress from bench to bedside. Current opinion in lipidology.14(4):361-366.## Renner W, Cichocki L, Forjanics A. 2002. G-455A polymorphism of the fibrinogen beta gene and deep vein thrombosis. Eur J Clin Invest. 32(7):755–758.## Kasapis C, Thompson PD. 2005. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol. 45(10):1563-1569.## Lin YH, Chu LL, Kao CC, Chen TB, Lee I, Li HC. 2015. The Effects of a Diet and Exercise Program for Older Adults with Metabolic Syndrome. J Nurs Res. 4(4):5-17.## Amaral F, Lima NE, Ornelas E, Simardi L, Fonseca FL, Maifrino LB. 2015. Effect of different exercise intensities on the pancreas of animals with metabolic syndrome. Diabetes Metab Syndr Obes.13(8):115-120.## Conceição MS, Bonganha V, Vechin FC, Berton RP, Lixandrão ME, Nogueira FR, et al. 2013. Sixteen weeks of resistance training can decrease the risk of metabolic syndrome in healthy postmenopausal women. Clin Interv Aging. 8(12):21-28.## Zafari A. 2012. The Effects of Exercise Training on Coronary Artery Disease Risk Factors. Eur J Exp Biol. 2(5):1404-1407. ## Elkayam A, Peleg E, Grossman E, Shabtay Z, Sharabi Y. 2013. Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J. 15(3):170-173.## Gorinstein S, Leontowicz H, Leontowicz M, Drzewiecki J, Najman K, Katrich E, et al. 2006. Raw and boiled garlic enhances plasma antioxidant activity and improves plasma lipid metabolism in cholesterol-fed rats. Life Sci. 78(6):655-663.## Powolny AA, Singh SV. 2008. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett. 269(2):305-314.## Shirai, T, Shichi Y, Sato M, Tanioka Y, Furusho T, Ota T. 2016. High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism. Nutr Res. 36(3):262-270.## Lee mo. 1929. determination of the surface area of the white rat with it's application to the expression of metabolic results. Am J Physiol. 89(1):24-33.## Heo M, Kim E.2013. Effects of Endurance Training on Lipid Metabolism and Glycosylated Hemoglobin Levels in Streptozotocin-induced Type 2 Diabetic Rats on a High-fat Diet. J Phys Therap Sci. 25(8):989-992.## Esfahani PS, Gharakhanlou R, Karimian J, Khazaei M, Feizi A, Safarzade A. 2013. Effect of Resistance Training on Plasma Nitric Oxide and Asymmetric Dimethylarginine Concentrations in Type I Diabetic Rats. Int J Pre Med. 4(1):78–84.## Piyaporn T, Wanassanun P, Jariya UW, Wunnee C, Kittisak S, Bungorn S. 2017. Effects of Aged Garlic Extract on Cholinergic, Glutamatergic and GABAergic Systems with Regard to Cognitive Impairment in Aβ-Induced Rats. Nutr. 9(7):686. ## Hejazi M, Rashidlamir A, Jebbelli A, Nornematollahi S, Ghazavi M, Soltani M. 2013. The effects of 8 weeks’ aerobic exercise on levels of homocysteine, HS-CRP serum and plasma fibrinogen in type II diabetic women. Life Sci J.10(1s):430-435.## Vincent KR, Braith RW, Bottiglieri T, Vincent HK, Lowenthal DT. 2003. Homocysteine and lipoprotein levels following resistance training in older adults. Prev Cardiol. 6(4):197-203.## Seo DY, Lee SR, Kim HK, Baek YH, Kwak YS, Ko TH, et al. 2012. Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women. Nutr Res Pract. 6(3):226-231.## Morihara N, Ide N, Weiss N. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. 2011. J Ethnopharmacol. 134(3):711-716.## Stefano B, Alice C, Giampietro A, Ileana T, Nicoletta D, Antonio LT, Livio L. 2010. Increase in homocysteine levels after a half-marathon running: a detrimental metabolic effect of sport? Sport Sci Health. 1:35–42.## Martins RA, Neves AP, Coelho-Silva MJ, Veríssimo MT, Teixeira AM. 2010. The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults. Eur J Appl Physiol. 110(1):161-169.## Seo DY, Lee S, Figueroa A, Kwak YS, Kim N, Rhee BD, et al. 2012. Aged garlic extract enhances exercise-mediated improvement of metabolic parameters in high fat diet-induced obese rats. Nutr Res Pract. 6(6):513-519.## Libardi CA, De Souza GV, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. 2012. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc. 44(1):50-56.## Aalami-Harandi R, Karamali M, Asemi Z. 2015. The favorable effects of garlic intake on metabolic profiles, hs-CRP, biomarkers of oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia: randomized, double-blind, placebo-controlled trial. J Matern Fetal Neonatal Med. 28(17):2020-2027.## Ried K, Travica N, Sali A. 2016. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Integr Blood Press Control. 27:9-21.## van Doorn MB, Espirito Santo SM, Meijer P, Kamerling IM, Schoemaker RC, Dirsch V, et al. 2006. Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects. Am J Clin Nutr. 84(6):1324-1329.## Durstine JL, Davis PG, Ferguson MA, Alderson NL, Trost SG. 2001. Effects of short-duration and long-duration exercise on lipoprotein(a). Med Sci Sports Exerc. 33(9):1511-1516.## Drowatzky KL, Durstine JL, Irwin ML, Moore CG, Davis PG, Hand GA, et al. 2001. The association between physical activity, cardiorespiratory fitness, and lipoprotein(a) concentrations in a tri-ethnic sample of women: The Cross-Cultural Activity Participation Study. Vasc Med. 6(1):15-21.## Hubinger L, Mackinnon LT. 1996. The effect of endurance training on lipoprotein(a) [Lp(a)] levels in middle-aged males. Med Sci Sports Exerc. 28(6):757-764.## Rigla M, Sánchez-Quesada JL, Ordóñez-Llanos J, Prat T, Caixàs A, Jorba O, et al. 2000. Effect of physical exercise on lipoprotein(a) and low-density lipoprotein modifications in type 1 and type 2 diabetic patients. Metabolism. 49(5):640-647.## Superko HR, Krauss RM. 2000. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein (a). J Am Coll Cardiol. 35:321–326.## Isaacsohn JL, Moser M, Stein EA, Dudley K, Davey JA, Liskov E, et al. 1998. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med. 158:1189–1194.## Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med. 2009;49(2-3):101-7.##