تازه های تحقیق
عنوان مقاله [English]
Background &Purpose: lipocalin-2 is a novel adipokine that is highly expressed by white adipose tissue and is likely to be effective on glucose metabolism and insulin sensitivity. The purpose of this study was to investigate the effect of eight weeks of circuit resistance training on plasma lipocalin-2 levels in diabetic men.
Methodology: Sixteen men with type 2 diabetes (age 49.2 ± 7.9 yr, weight 81.6 ± 11.4 kg, and BMI 28.1 ± 3.9) were randomly divided into control (n=8) and resistance training (n=8) groups. Subjects in training group performed eight weeks circuit resistance training with 50-80% 1RM (3 days/week). Anthropometrics parameters and fasting plasma glucose, insulin, and Lipocalin-2, as well as glycosylated haemoglobin (HbA1c), insulin resistance index (HOMA-IR), and white blood cell count (WBC) were measured at baseline and at the end of study.
Results: Resistance training induced significant reductions in fasting plasma insulin, HbA1c and WBC levels in diabetic men (P < 0.05). Significant changes in plasma glucose concentration and HOMA-IR scores were found when compared with control group (P < 0.05). Plasma lipocalin-2 concentration increased in training group (P < 0.05), and this alteration was statistically significant when compared with control group (P < 0.05).
Conclusion: Our findings showed that circuit resistance training can be an effective intervention to improve metabolic and inflammatory profile in type 2 diabetic men. Increased plasma concentrations of lipocalin-2 may represent a compensatory mechanism to improve the metabolism in these patients.
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