تاثیر تمرین مقاومتی بر غلظت پلاسمایی لیپوکالین-2، تعداد سلول‌های سفید خون و شاخص مقاومت به انسولین در مردان مبتلا به دیابت نوع 2

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران

2 گروه فیزیولوژی ورزش، دانشگاه آزاد ساری، ساری، ایران.

چکیده

سابقه و هدف: لیپوکالین-2 آدیپوکینی است که به میزان بالایی در بافت چربی سفید بیان می­شود و به نظر می­رسد بر متابولیسم گلوکز و حساسیت انسولینی اثرگذار باشد. هدف پژوهش حاضر بررسی تاثیر 8 هفته تمرین مقاومتی دایره­ای بر سطوح پلاسمایی لیپوکالین-2 مردان دیابتی بود.
مواد و روش­ها: شانزده مرد مبتلا به دیابت نوع 2 با میانگین سن 7.9 ± 49.2 سال، وزن 11.4 ± 81.6 کیلوگرم و شاخص توده بدن 3.9 ± 28.1 به طور تصادفی به دو گروه کنترل (تعداد = 8) و تمرین مقاومتی (تعداد = 8) تقسیم شدند. آزمودنی­های گروه تمرین 8 هفته تمرین مقاومتی دایره­ای با شدت 50 تا 80 درصد یک تکرار بیشینه را (3 روز در هفته) انجام دادند. شاخص­های پیکرسنجی و سطوح ناشتای گلوکز، انسولین و لیپوکالین-2 پلاسمایی همراه با هموگلوبین گلیکوزیله (HbA1c)، شاخص مقاومت انسولینی (HOMA-IR) و تعداد سلول­های سفید خون (WBC) در ابتدا و پایان مطالعه مورد ارزیابی قرار گرفت.
یافته­ها: تمرین مقاومتی موجب کاهش معنی­دار سطوح پلاسمایی انسولین، HbA1c و WBC مردان دیابتی شد (0.05>P). تغییرات غلظت پلاسمایی گلوکز و مقادیر HOMA-IR در گروه تمرین مقاومتی در مقایسه با گروه کنترل معنی­دار بود (0.05>P). غلظت پلاسمایی لیپوکالین-2 در گروه تمرین با افزایش همراه بود (0.05>P) که این تغییرات تفاوت معنی­داری در مقایسه با گروه کنترل داشت (0.05>P).
بحث و نتیجه­ گیری: یافته­های تحقیق حاضر بیانگر آن است که تمرین مقاومتی دایره­ای می­تواند روش مداخله­ی موثری در بهبود نیم­رخ متابولیکی و التهابی در مردان مبتلا به دیابت نوع 2 باشد. افزایش غلظت پلاسمایی لیپوکالین-2 احتمالاً ساز و کاری جبرانی در بهبود متابولیسم این بیماران است.

تازه های تحقیق

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کلیدواژه‌ها


عنوان مقاله [English]

Effect of Resistance Training on Plasma Lipocalin-2 Concentration, White Blood Cell Count, and Insulin Resistance Index in Type 2 Diabetic Men

نویسندگان [English]

  • Alireza Safarzade 1
  • Hasan Barzegari-Marzoni 2
  • Elahe Talebi-Garakani 1
  • Rozita Fathi 1
1 Department of exercise physiology, sport science faculty, University of Mazandaran, Babolsar, Iran
چکیده [English]

Background &Purpose: lipocalin-2 is a novel adipokine that is highly expressed by white adipose tissue and is likely to be effective on glucose metabolism and insulin sensitivity. The purpose of this study was to investigate the effect of eight weeks of circuit resistance training on plasma lipocalin-2 levels in diabetic men.
Methodology: Sixteen men with type 2 diabetes (age 49.2 ± 7.9 yr, weight 81.6 ± 11.4 kg, and BMI 28.1 ± 3.9) were randomly divided into control (n=8) and resistance training (n=8) groups. Subjects in training group performed eight weeks circuit resistance training with 50-80% 1RM (3 days/week). Anthropometrics parameters and fasting plasma glucose, insulin, and Lipocalin-2, as well as glycosylated haemoglobin (HbA1c), insulin resistance index (HOMA-IR), and white blood cell count (WBC) were measured at baseline and at the end of study.
Results: Resistance training induced significant reductions in fasting plasma insulin, HbA1c and WBC levels in diabetic men (P < 0.05). Significant changes in plasma glucose concentration and HOMA-IR scores were found when compared with control group (P < 0.05). Plasma lipocalin-2 concentration increased in training group (P < 0.05), and this alteration was statistically significant when compared with control group (P < 0.05).
Conclusion: Our findings showed that circuit resistance training can be an effective intervention to improve metabolic and inflammatory profile in type 2 diabetic men. Increased plasma concentrations of lipocalin-2 may represent a compensatory mechanism to improve the metabolism in these patients.

کلیدواژه‌ها [English]

  • Siderocalin
  • Resistance Training
  • Type 2 Diabetes
  • systemic Inflammation
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