عنوان مقاله [English]
Background & Purpose: Vascular endothelial growth factor (VEGF) was known as the main specific mitogen for vascular endothelial cells. The purpose of the present study was to examine the effects of high-intensity interval exercise on serum VEGF changes in trained and untrained men.
Methodology: Twelve male subjects recruited and assigned into two groups trained (n=6) and untrained (n=6) according to physical activity levels. One week before the experiment was started; subjects were familiar with protocol of research. High-intensity interval exercise protocol included of 12×1min intervals at ∼85-90% of reserve heart rate separated by 1min of active recovery. Blood samples were collected from both groups before, immediately after, three and five hours after doing high-intensity interval exercise. Also, serum VEGF was measured by ELISA kit and data were analyzed by using independent t-test and analysis of variance with repeated measures at the level of significance of P≤0.05.
Results: Results of study showed levels of Serum VEGF, immediately after high-intensity interval exercise increased in trained but decreased in untrained men. Also, significant differences were observed between serum VEGF level changes of trained and untrained men in response to exercise (P≤0.05).
Conclusion: Physical fitness status can be of the effective factors in changes model of serum VEGF in response to a session of high-intensity interval exercise.
##Bayati M, Gharakhanlou R, Agha-Alinejad H, Farzad B. 2010. The effect of 4 weeks of high-intensity interval training on selected physiological and metabolic indices in active men. Journal of Applied Exercise Physiology. 6(11):107-124 (Persian).## Billaut F, Bishop D. 2009. Muscle fatigue in males and females during multiple-sprint exercise. Sports medicine. 39(4):257-278.## Bayati M, Gharakhanlou R, Agha-Alinejad H, Farzad B. 2011. Effects of high-intensity sprint interval training program on aerobic and anaerobic performances in untrained men. Sport Physiology. 8(1):25-40 (Persian).##Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA. 2006. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. The Journal of physiology. 575(Pt 3):901-911.## Burgomaster KA, Hughes SC, Heigenhauser GJ, Bradwell SN, Gibala MJ. 2005. Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. Journal of applied physiology. 98(6):1985-1990.## Burgomaster KA, Howarth KR, Phillips SM, Rakobowchuk M, Macdonald MJ, McGee SL, Gibala MJ. 2008. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. The Journal of physiology. 586(1):151-160.## Gibala MGM. 2009. Molecular responses to high-intensity interval exercise. Applied Physiology, Nutrition, and Metabolism. 34(3):428-432.## Djonov V, Baum O, Burri PH. 2003. Vascular remodeling by intussusceptive angiogenesis. Cell and tissue research. 314(1):107-117.## Wahl P, Jansen F, Achtzehn S, Schmitz T, Bloch W, Mester J, Werner N. 2014. Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors. PLoS One. 9(4):e96024.## Gu JW, Gadonski G, Wang J, Makey I, Adair TH. 2004. Exercise increases endostatin in circulation of healthy volunteers. BMC physiology. 4:2.## Wahl P, Zinner C, Achtzehn S, Behringer M, Bloch W, Mester J. 2011. Effects of acid-base balance and high or low intensity exercise on VEGF and bFGF. European journal of applied physiology. 111(7):1405-1413.## Ravasi A, Yadegari M, Choobineh S. 2014. Comparison of two types of physical activity on response serum VEGF-A, non-athletic men. Journal of Sports Biosciences. 6(1):41-56 (Persian).## Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. 2003. International physical activity questionnaire: 12-country reliability and validity. Medicine and science in sports and exercise. 35(8):1381-1395.## Mikkelsen UR, Couppé C, Karlsen A, Grosset JF, Schjerling P, Mackey AL, Klausen HH, Magnusson SP, Kjær M. 2013. Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size. Mechanisms of ageing and development. 134(11-12):531-540.## Bothe N, Zschucke E, Dimeo F, Heinz A, Wüstenberg T, Ströhle A. 2013. Acute exercise influences reward processing in highly trained and untrained men. Medicine and science in sports and exercise. 45(3):583-591.## Tanaka H, Monahan KD, Seals DR. 2001. Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology. 37(1):153-156.## American College of Sports Medicine. 2013. ACSM's Guidelines for Exercise Testing and Prescription. Ninth Edition, Philadelphia, Lippincott Williams & Wilkins, 169.## Hood MS, Little JP, Tarnopolsky MA, Myslik F, Gibala MJ. 2011. Low-volume interval training improves muscle oxidative capacity in sedentary adults. Medicine and Science in Sports and Exercise. 43(10):1849-1856.## Kraus RM, Stallings HW, Yeager RC, Gavin TP. 2004. Circulating plasma VEGF response to exercise in sedentary and endurance-trained men. Journal of Applied Exercise Physiology. 96(4):1445-1450.## Ranjbar K, Nourshahi M, Hedayati M, Taheri-Chadorneshin H. 2011. Effect of gender and physical activity on serum vascular endothelial growth factor at rest and response to submaximal exercise. Iranian Journal of Endocrinology and Metabolism. 13(3):294-300 (Persian).## Czarkowska-Paczek B, Bartlomiejczyk I, Przybylski J. 2006. The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society. 57(2):189-197.## Ranjbar K, Nourshahi M, Hedayati M, Taheri H. 2011. A study on the serum levels of angiogenic factors in response to acute long-term submaximal exercise in sedentary men. Physiology and Pharmacology. 15(1):124-132 (Persian).## Taheri-Chadorneshin H, Nourshahi M, Ranjbar K. 2010. The response of vascular endothelial growth factor to exhausted submaximal exercise and its relationship with Vo2max. Journal of Sports Biosciences. 2(7):59-75 (Persian).##Thorell D, Borjesson M, Larsson P, Ulfhammer E, Karlsson L, DuttaRoy S. 2009. Strenuous exercise increases late outgrowth endothelial cells in healthy subjects. European journal of applied physiology. 107(4):481-488.## Hoier B, Hellsten Y. 2014. Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF. Microcirculation. 21(4):301-314.##