پاسخ متفاوت VEGF سرمی در مردان تمرین‌کرده و تمرین‌نکرده به ورزش تناوبی شدید

نوع مقاله: مقاله پژوهشی

نویسندگان

1 استادیار گروه فیزیولوژی ورزشی، پژوهشکده طب ورزشی، پژوهشگاه تربیت بدنی و علوم ورزشی، تهران، ایران.

2 دانشیار گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران.

3 کارشناسی ارشد فیزیولوژی ورزشی، دانشگاه خوارزمی، تهران، ایران.

4 استادیار گروه ریز زیست فناوری، دانشکده علوم زیستی، دانشگاه تربیت مدرس، تهران، ایران.

5 دکتری تخصصی فیزیولوژی ورزشی، تهران،ایران

چکیده

سابقه و هدف: فاکتور رشد اندوتلیال عروق (VEGF) به­عنوان مهمترین میتوژن مخصوص سلول­های اندوتلیال عروقی شناخته شده است. هدف از پژوهش حاضر، بررسی اثر ورزش تناوبی شدید بر تغییرات VEGF سرمی در مردان تمرین­کرده و تمرین­نکرده بود.
مواد و روش­ها: 12 مرد به­طور هدفمند براساس سابقه تمرین در دو گروه تمرین­کرده (6 نفر) و تمرین­نکرده (6 نفر) شرکت کردند. آزمودنی­ها یک هفته پیش از آغاز اجرای پژوهش با نحوه اجرا و چگونگی انجام برنامه آشنا شدند. پروتکل ورزش تناوبی شدید شامل 12 وهله 1 دقیقه­ای با 90-85 درصد ضربان قلب ذخیره­ای و 1 دقیقه برگشت به حالت اولیه فعال بین هر وهله بود. نمونه­گیری خون قبل، بلافاصله، 3 و 5 ساعت بعداز ورزش تناوبی شدید انجام شد. سطوح VEGF سرمی با کیت الایزا اندازه­گیری و داده­ها با آزمون­های تی مستقل و تحلیل واریانس با اندازه­های تکراری در سطح معناداری 05/0P≤ تجزیه­و­تحلیل شدند.
یافته ­ها: نتایج پژوهش نشان داد که VEGF سرمی بلافاصله پس از ورزش تناوبی شدید در مردان تمرین­کرده افزایش، ولی در مردان تمرین­نکرده کاهش یافت. هم­چنین بین تغییرات سطوح VEGF سرمی مردان تمرین­کرده و تمرین­نکرده در پاسخ به ورزش تفاوت معنی­داری مشاهده شد (05/0P≤).
نتیجه­ گیری: سطح آمادگی افراد می­تواند از عوامل موثر در الگوی تغییرات VEGF سرمی در پاسخ به یک جلسه ورزش تناوبی شدید ­باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Different Responses of Serum VEGF in Trained and Untrained Men to High-intensity Interval Exercise

نویسندگان [English]

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چکیده [English]

Background & Purpose: Vascular endothelial growth factor (VEGF) was known as the main specific mitogen for vascular endothelial cells. The purpose of the present study was to examine the effects of high-intensity interval exercise on serum VEGF changes in trained and untrained men.
Methodology: Twelve male subjects recruited and assigned into two groups trained (n=6) and untrained (n=6) according to physical activity levels. One week before the experiment was started; subjects were familiar with protocol of research. High-intensity interval exercise protocol included of 12×1min intervals at ∼85-90% of reserve heart rate separated by 1min of active recovery. Blood samples were collected from both groups before, immediately after, three and five hours after doing high-intensity interval exercise. Also, serum VEGF was measured by ELISA kit and data were analyzed by using independent t-test and analysis of variance with repeated measures at the level of significance of P≤0.05.
Results: Results of study showed levels of Serum VEGF, immediately after high-intensity interval exercise increased in trained but decreased in untrained men. Also, significant differences were observed between serum VEGF level changes of trained and untrained men in response to exercise (P≤0.05).
Conclusion: Physical fitness status can be of the effective factors in changes model of serum VEGF in response to a session of high-intensity interval exercise.
 

کلیدواژه‌ها [English]

  • Angiogenesis
  • Vascular Endothelial Growth Factor
  • Fitness
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