تاثیر تزریق واکسن آنفلوانزا بر شاخص های پیش التهابی و ضد التهابی در ژیمناست های پسر نابالغ

نوع مقاله: مقاله پژوهشی

نویسنده

استادیار دانشگاه آزاداسلامی واحد ساری

چکیده

    زمینه و هدف: اثر یک جلسه تمرین حاد قبل از واکسیناسیون بر بهبود پاسخ ایمنی بررسی شده، پاسخ ایمنی پس از یک دوره تمرین، هنوز ناشناخته مانده است. هدف این مطالعه ،تاثیر تزریق واکسن آنفلوانزا  بر شاخص های های پیش التهابی و ضد التهابی در ژیمناست های پسر نابالغ بود.
    مواد و روش­ها: 30 ژیمناست پسر نوجوان به دو گروه تمرین-واکسن (گروه واکسن) و گروه تمرین بدون واکسن (گروه کنترل) تقسیم شدند. هر دو گروه برنامه تمرینی منتخب ژیمناستیک را با شدت میانگین 80-60 درصد ضربان قلب بیشینه به مدت هشت هفته و هر هفته 3 جلسه اجرا کردند. به منظور تعیین تغییرات غلظت های سرمی اینترلوکین-6(IL-6)، اینترلوکین-10(IL-10) و اینترفرون-گاما(IFN-γ)نمونه های خونی در هفته های اول، چهارم و هشتم جمع آوری شد.
 یافته­ها: نتایج نشان داد IL-6 و INFγ پس از چهار هفته در هر دو گروه کاهش معنی دار یافت(0001/0=P و01/0=P به ترتیب). تفاوت معنی دار در هفته هشتم فقط در گروه واکسن دیده شده است. روند کاهش  INFγدر هفته هشتم در گروه کنترل ادامه یافت، اما این کاهش معنی­دار نبود. تفاوت معنی­دار در INFγ پس از هفته چهارم و هشتم فقط در گروه واکسن مشاهده شده است.  IL-10 در مقایسه با پیش فعالیت در هر دو گروه افزایش یافت (006/0=P). تفاوت معنی­دار در  IL-10 پس از هفته چهارم و هشتم در هر دو گروه مشاهده شده ا ست.
 بحث و نتیجه­گیری: این نتایج نشان می­دهد که تزریق واکسن آنفلوانزا تأثیر قابل توجهی بر دستگاه ایمنی و حالت التهابی خون ژیمناست­های پسر نوجوان دارد.

کلیدواژه‌ها


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