تاثیر یک دوره تمرین اینتروال استقامتی به همراه نانوذرات سلنیوم بر کاچکسی عضلانی در موش های مبتلا به سرطان پستان

نوع مقاله: مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی وعلوم ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس

2 گروه ایمونولوژی پزشکی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس

چکیده

مقدمه و هدف: کاچکسی سرطان به عنوان از دست دادن وزن، بی اشتهایی، آتروفی عضلانی، کاهش قدرت و عملکرد عضلانی و خستگی تعریف می­شود. با توجه به اثرات آنتی اکسیدانی نانوذرات سلنیوم و تمرینات ورزشی استقامتی هدف از پژوهش حاضر بررسی تاثیر یک دوره تمرین اینتروال هوازی به همراه نانوذرات سلنیوم به صورت خوراکی بر کاچکسی عضلانی در موش های مبتلا به سرطان پستان بود.
روش شناسی پژوهش: تعداد 64 سر موش بالب سی به شکل تصادفی به 8 گروه سالم - کنترل، تومور - کنترل، سالم - تمرین، تومور - تمرین، سالم - نانو ذرات سلنیوم، تومور - نانو ذرات سلنیوم، سالم - تمرین - نانو ذرات سلنیوم، تومور- تمرین - نانو ذرات سلنیوم تقسیم شدند. نمونه های پژوهش در گروه­های تمرینی و مصرف کننده نانوذره تمرین اینتروال هوازی و نانوذرات سلنیوم را به مدت 6 هفته دریافت کردند. وزن غذای مصرفی، وزن بدن، وزن بدن بدون وزن تومور، وزن عضله دوقلو و همچنین تست های وزنه و صفحه معکوس برای برآورد عملکرد عضلانی از موش­ها گرفته شد.
نتایج: نتایج پژوهش نشان دهنده کاهش معنادار وزن بدن بدون تومور در اثر استفاده از نانوذره بوده است (P  نتیجه گیری: به نظر می رسد نانوذرات سلنیوم به تنهایی در تشدید وضعیت کاچکسی تاثیر دارند ترکیب این نانوذرات با تمرینات ورزشی توانسته است تا حدی از ایجاد کاچکسی و کاهش قدرت عضلانی جلوگیری کند.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Endurance Interval Training with Selenium Nanoparticles on Skeletal Muscle Cachexia in Mice with Breast Cancer

نویسندگان [English]

  • Soodabeh Chekachak 1
  • Mahdieh Molanouri Shamsi 1
  • Sara Soudi 2
  • Kia Ranjbar 1
1 Physical Education & Sport Sciences Dept., Faculty of Humanities, Tarbiat Modares University
2 Department of Immunology, School of Medical Sciences, Tarbiat Modares University
چکیده [English]

Back graund & purpose: Cancer cachexia has introduced as anorexia, weight loss, skeletal muscle atrophy, decreases in strength and action in skeletal muscle and fatigue.  With considering to antioxidant effects of selenium nano-particles and exercise training, the aim of this study was to examine the effects of aerobic interval exercise training and oral supplementation of selenium nanoparticles on cachexia situation in mice with breat cancer.
 Material and methods: 64 mice were randomly divided into 8 group includes Control-Health, Control-Tumor, Training-Healthy, Training-Tumor, Selenium Nanoparticles-Health, Selenium Nanoparticles-Tumor, Selenium Nanoparticles-Training-Health and Selenium Nanoparticles–Training-Tumor. Samples in traning and nanparticles groups have done aerobic interval training and have supplemented with selenium nanoparticles. Muscle mass, body weight, food intake, and weight and inverted performance exercise tests were used to confirm cachexia in animals.
 Results: The results of this study have shown that body weight without tomur significantly decreased in mice that supplemented with Selenium nanoparticles (PConclusion: skeletal muscle cachexia was observed in current study in breast cancer mice. It seems that selenium nano-particles intensified cachexia situation but combination of exercise training and nano-particles maintained skeletal muscle mass and prevented cachexia.
 

کلیدواژه‌ها [English]

  • Endurance training
  • Selenium Nanoparticles
  • Cancer
  • Cachexia
  • Skeletal muscle
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