بررسی تغییرات شاخص های بافتی، سرمی کبد و سندروم متابولیک در بیماران مبتلا به کبد چرب غیر الکلی طی دوره ی 36 جلسه ای تمرین ورزشی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار گوارش کودکان، مرکز تحقیقات چاقی مادر و کودک، دانشگاه علوم پزشکی ارومیه، بیمارستان مطهری، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

3 آموزشکده فنی و حرفه ای سما، دانشگاه آزاد اسلامی، واحد ارومیه، ارومیه، ایران

4 رادیولوژیست، دانشگاه علوم پزشکی ارومیه، بیمارستان مطهری، ارومیه، ایران.

5 فوق تخصص قلب، فلوشیپ الکتروفیزیولوژی و پیس میکر، استادیار، بیمارستان سیدالشهدا، دانشگاه علوم پزشکی ارومیه، ارومیه ایران

چکیده

سابقه و هدف: امروزه شیوع چاقی و اضافه وزن که زاییده‌ی سبک زندگی بدون تحرک و رژیم‌های غذایی نامناسب می‌باشد، از مشکلات اصلی سلامت محسوب می‌شود که یکی از عوارض آن، بیماری کبد چرب غیر الکلی (NAFLD) است، هدف این مطالعه بررسی تغییرات شاخص‌های بافتی، سرمی کبد و سندروم متابولیک در بیماران مبتلا به کبد چرب غیر الکلی طی یک دوره تمرین ورزشی بود.
مواد و روش ها: در این مطالعه نیمه تجربی تصادفی، 29 زن اضافه وزن و چاق دارای استئاتوز کبد با دامنه‎ی سنی 22 تا 52 سال، به طور تصادفی به دو گروه فعالیت ورزشی هوازی (13 نفر) و کنترل (16نفر) تقسیم شدند. گروه هوازی (12 هفته تمرین هوازی را 3 جلسه در هفته، هرجلسه 50 -20 دقیقه، با شدت 70-50 % حدکثر ضربان قلب) انجام دادند. گروه کنترل طی این 12 هفته بدون تمرین بودند. نمونه‌های خونی جهت تعیین سطوح آنزیم‌های آسپارتات آمینوترانسفراز (SGOT)، آلکالین فسفاتاز (ALK)، آلانین آمینوترانسفراز (SGPT) و تری گلیسیرید (TG)، کلسترول (CHO) ،HDL ، LDL  در مراحل پیش و پس آزمون جمع‌آوری شدند. تحلیل آماری نتایج با استفاده از نرم افزار SPSS  نسخه 21 انجام گرفت.
یافته ها:  با توجه به نتایج، از شاخص های آنتروپومتریکی، تنها دور کمر و از متغیرهای بیوشیمیایی، تنها آنزیم ALK و کلسترول تام بین دو گروه تجربی و کنترل، دارای تغییرات معنی‌دار بودند (05/0≥P) و تغییرات شاخص‌های دیگر غیر معنی‌دار بود(05/0˃P).
 نتیجه گیری: با توجه به تغییرات معنی‌دار شاخص­های معدودی از پژوهش، به نظر می‌رسد  اجرای 12 هفته تمرینات هوازی به روش مذکور، حداقل راهکار مناسب برای مدیریت و کنترل کبد چرب و عوارض ناشی از آن باشد.
 

کلیدواژه‌ها


عنوان مقاله [English]

Investigation of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during 36 sessions of exercise training

نویسندگان [English]

  • Gheibi Shahsanam 1
  • Asghar Tofighei 2
  • zahra samadian 3
  • Yalda Saniei 4
  • Mojgan hajahmadi pour Rafsanjani 5
1 Associate professor of Pediatric Gastroenterology, Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Shahid Motahari Hospital, Urmia, Iran.
2 Associate professor of exercise physiology, Faculty of Sport Sciences, Urmia university, Urmia,
3 Sama Technical and Vocational Training College, Islamic Azad University, Urmia Branche, Urmia, Iran
4 Radiologists, Urmia University of Medical Sciences, Shahid Motahari Hospital, Urmia, Iran
5 cardiologist, fellowship electrophysiology and pacemaker, professor assistant, seyyed al shohada hospital, Urmia University of Medical Sciences, Urmia, Iran
چکیده [English]

Background and purpose: Prevalence of overweight and obesity caused by a sedentary lifestyle and poor diet is the problem of health that one of its side effects is Non-Alcoholic Fatty Liver Disease (NAFLD). The aim of this study was to investigate of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during a period of exercise training.
Methodology: In this randomized controlled trial, 29 overweight and obese women with liver steatosis with an age range of 22 to 52 years, were randomly divided into two groups: aerobic exercise (n = 13) and control (n = 16). Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate). The control group was sedentary during the same period. Blood samples to determine levels of liver enzymes (SGOT, ALK, SGPT) and serum lipid profile (TG, CHO, HDL, LDL) were collected before and after the test. Data were analyzed using SPSS version 21.
Results:  The results show significant changes of anthropometric parameters (waist circumference) and biochemical variables (ALK and total cholesterol) between the two-experimental and control groups(p≤0/05).
Conclusion: Due to significant changes in a few indicators of the study, 12 weeks of aerobic exercise seems to be at least appropriate way to manage and control the fatty liver and its complications.
 

کلیدواژه‌ها [English]

  • Aerobic exercise training
  • non-alcoholic fatty liver disease (NAFLD)
  • Lipid Profile

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