##Sun H, Yang Y, Shao H, Sun W, Gu M, Wang H, et al. Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus. Frontiers in Molecular Neuroscience. 2017;10:286.##Gao B, Zhang X-y, Han R, Zhang T-t, Chen C, Qin Z-h, et al. The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning. Acta Pharmacologica Sinica. 2013;34(5):657-66.##Svensson M, Lexell J, Deierborg T. Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings. Neurorehabilitation and Neural Repair. 2014;29(6):577-89.##Inoue K, Hanaoka Y, Nishijima T, Okamoto M, Chang H, Saito T, et al. Long-term mild exercise training enhances hippocampus-dependent memory in rats. International journal of sports medicine. 2015;36(04):280-5.##Wagner G, Herbsleb M, de la Cruz F, Schumann A, Brünner F, Schachtzabel C, et al. Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015;35(10):1570-8.##Freitas DA, Rocha-Vieira E, Soares BA, Nonato LF, Fonseca SR, Martins JB, et al. High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats. Physiology & behavior. 2018;184:6-11.##Kang E-B, Kwon I-S, Koo J-H, Kim E-J, Kim C-H, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18(11):1332-47.##Binu P, Priya N, Abhilash S, Vineetha RC, Nair RH. Studies on curative efficacy of monoterpene eugenol on anti- leukemic drug arsenic trioxide induced cardiotoxicity. Biomedicine & pharmacotherapy. Biomedecine & pharmacotherapie. 2017;91:559-66.##Freitas RM, Vasconcelos SMM, Souza FCF, Viana GSB, Fonteles MMF. Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats. The FEBS Journal. 2005;272(6):1307-12.##Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience. 2019;406:1-21.##Yadav RS, Shukla RK, Sankhwar ML, Patel DK, Ansari RW, Pant AB, et al. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. NeuroToxicology. 2010;31(5):533-9.##Farkhondeh T, Samarghandian S, Samini F. Antidotal effects of curcumin against neurotoxic agents: An updated review. Asian Pacific journal of tropical medicine. 2016;9(10):947-53.##Hosseinzadeh S, Roshan VD, Mahjoub S. Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats. Pharmaceutical biology. 2013;51(2):240-5.##Mai Z, Liu H. Boolean network-based analysis of the apoptosis network: Irreversible apoptosis and stable surviving. Journal of Theoretical Biology. 2009;259(4):760-9.##Hemmati AA, Olapour S, Varzi HN, Khodayar MJ, Dianat M, Mohammadian B, et al. Ellagic acid protects against arsenic trioxide–induced cardiotoxicity in rat. Human & Experimental Toxicology. 2017;37(4):412-9.##Biswas J, Roy S, Mukherjee S, Sinha D, Roy MJAPjocpA. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. 2010;11(1):239.##Escudero-Lourdes C. Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: role of oxidative stress and inflammatory responses. Neurotoxicology. 2016;53:223-35.##Wolfe MS. Preface. The Molecular and Cellular Basis of Neurodegenerative Diseases: Elsevier; 2018. p. xiii-xiv.##Porter AG, Jänicke RUJCd, differentiation. Emerging roles of caspase-3 in apoptosis. 1999;6(2):99-104.##D'Amelio M, Cavallucci V, Cecconi F. Neuronal caspase-3 signaling: not only cell death. Cell Death & Differentiation. 2010;17(7):1104-14.##Selvaraj V, Armistead MY, Cohenford M, Murray E. Arsenic trioxide (As(2)O(3)) induces apoptosis and necrosis mediated cell death through mitochondrial membrane potential damage and elevated production of reactive oxygen species in PLHC-1 fish cell line. Chemosphere. 2013;90(3):1201-9.##Manthari RK, Tikka C, Ommati MM, Niu R, Sun Z, Wang J, et al. Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood–brain barrier’s tight junction proteins. 2018;92(11):3255-75.##Prasad P, Sinha DJES, Research P. Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors. 2017;24(12):11708-21.##Yen CC, Ho TJ, Wu CC, Chang CF, Su CC, Chen YW, et al. Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. 2011;85(6):565-75.##Ullah F, Liang A, Rangel A, Gyengesi E, Niedermayer G, Münch G. High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation. Archives of Toxicology. 2017;91(4):1623-34.##Squillaro T, Cimini A, Peluso G, Giordano A, Melone MAB. Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors. Biochemical Pharmacology. 2018;154:303-17.##Yadav RS, Shukla RK, Sankhwar ML, Patel DK, Ansari RW, Pant AB, et al. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. 2010;31(5):533-9.##Sarkar B, Dhiman M, Mittal S, Mantha AK. Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2. Metabolic Brain Disease. 2017;32(6):2045-61.##Hosseinzadeh S, Roshan VD, Mahjoub S. Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats. Pharmaceutical Biology. 2012;51(2):240-5.##Sun B-F, Wang Q-Q, Yu Z-J, Yu Y, Xiao C-L, Kang C-S, et al. Exercise prevents memory impairment induced by arsenic exposure in mice: implication of hippocampal BDNF and CREB. 2015;10(9).##Powers SK, Ji LL, Leeuwenburgh CJM, Sports Si, Exercise. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. 1999;31(7):987-97.##Mengesdorf T, Althausen S, Paschen WJMbr. Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression. 2002;104(2):227-39.##Lu T-H, Tseng T-J, Su C-C, Tang F-C, Yen C-C, Liu Y-Y, et al. Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways. 2014;224(1):130-40.##Hitomi J, Katayama T, Taniguchi M, Honda A, Imaizumi K, Tohyama MJNl. Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. 2004;357(2):127-30.##Tamura Y, Kunugi H, Ohashi J, Hohjoh HJMp. Epigenetic aberration of the human REELIN gene in psychiatric disorders. 2007;12(6):593-600.##Sun B-F, Wang Q-Q, Yu Z-J, Yu Y, Xiao C-L, Kang C-S, et al. Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB. PLoS ONE. 2015;10(9).##Bardullas U, Limón-Pacheco J, Giordano M, Carrizales L, Mendoza-Trejo M, Rodríguez VJT, et al. Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice. Toxicology and Applied Pharmacology. 2009;239(2):169-77.##Srivastava P, Yadav RS, Chandravanshi LP, Shukla RK, Dhuriya YK, Chauhan LKS, et al. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. Toxicology and Applied Pharmacology. 2014;279(3):428-40.##Chi L, Gao B, Tu P, Liu C-W, Xue J, Lai Y, et al. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mammalian genome 2018;29(1-2):63-79.##