##Skinner AC, Skelton JAJJp. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. 2014;168(6):561-6.##Khazaei S, Nooraliey P, Gholamaliee B, Keshvari Delavar M, Khazaei S, Jamorpour S, et al. The Prevalence of Obesity among Iranian Adolescents: A Meta-Analysis Study. Qom Univ Med Sci J. 2016;10(9):78-88.##Zhao X, Gang X, Liu Y, Sun C, Han Q, Wang GJJodr. Using metabolomic profiles as biomarkers for insulin resistance in childhood obesity: a systematic review. 2016;2016.##Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014;15(4):6184-223.##Gibney MJ, Walsh M, Brennan L, Roche HM, German B, Van Ommen BJTAjocn. Metabolomics in human nutrition: opportunities and challenges–. 2005;82(3):497-503.##Newgard CBJCm. Interplay between lipids and branched-chain amino acids in development of insulin resistance. 2012;15(5):606-14.##Tricò D, Prinsen H, Giannini C, De Graaf R, Juchem C, Li F, et al. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents. 2017;102(7):2473-81.##Tai E, Tan M, Stevens R, Low Y, Muehlbauer M, Goh D, et al. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. 2010;53(4):757-67.##Lian K, Du C, Liu Y, Zhu D, Yan W, Zhang H, et al. Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice. Diabetes. 2015;64(1):49-59.##Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, et al. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. 2013;304(11):E1175-E87.##Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, et al. Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats. American Journal of Physiology-Endocrinology and Metabolism. 2011;300(1):E164-E74.##Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. Journal of Biological Chemistry. 2010;285(15):11348-56.##Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, et al. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. 2016;5(10):926-36.##She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJJAJoP-E, et al. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. 2007;293(6):E1552-E63.##Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. 2013;341(6150):1241214.##Olson KC, Chen G, Xu Y, Hajnal A, Lynch CJJO. Alloisoleucine differentiates the branched‐chain aminoacidemia of Zucker and dietary obese rats. 2014;22(5):1212-5.##Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. 2009;9(4):311-26.##Xiao F, Yu J, Guo Y, Deng J, Li K, Du Y, et al. Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice. 2014;63(6):841-50.##Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, et al. Metabolite profiles and the risk of developing diabetes. Nature medicine. 2011;17(4):448.##Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched-chain amino acid (BCAA) metabolism modulates circulating BCAA levels. Journal of Biological Chemistry. 2010:jbc. M109. 075184.##Patel TP, Rawal K, Bagchi AK, Akolkar G, Bernardes N, da Silva Dias D, et al. Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart failure reviews. 2016;21(1):11-23.##Marson EC, Delevatti RS, Prado AK, Netto N, Kruel LF. Effects of aerobic, resistance, and combined exercise training on insulin resistance markers in overweight or obese children and adolescents: A systematic review and meta-analysis. Prev Med. 2016;93:211-8.##Shimomura Y, Murakami T, Nakai N, Nagasaki M, Harris RAJTJon. Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. 2004;134(6):1583S-7S.##Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, et al. Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. 2015;58(10):2324-35.##Balikcioglu PG, Newgard CB. Metabolomic Signatures and Metabolic Complications in Childhood Obesity. Pediatric Obesity: Springer; 2018. p. 343-61.##Strasser B, Pesta DJBri. Resistance training for diabetes prevention and therapy: experimental findings and molecular mechanisms. 2013;2013.##Pesta DH, Goncalves RL, Madiraju AK, Strasser B, Sparks LMJN, metabolism. Resistance training to improve type 2 diabetes: working toward a prescription for the future. 2017;14(1):24.##Zachwieja JJ, Toffolo G, Cobelli C, Bier DM, Yarasheski KE. Resistance exercise and growth hormone administration in older men: effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabolism. 1996;45(2):254-60.##Roberts CK, Hevener AL, Barnard RJ. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Comprehensive Physiology. 2013.##Akbarpour M. The Effect of Resistance Training on Serum Levels of Adipokine and Inflammatory Markers of Cardiovascular Disease in Obese Men %J Qom Univ Med Sci J. 2013;7(3):1-10.##Vieira VJ, Valentine RJ, Wilund KR, Woods JA. Effects of diet and exercise on metabolic disturbances in high-fat diet-fed mice. Cytokine. 2009;46(3):339-45.##LEE S, GULSETH HL, REFSUM H, LANGLEITE TM, HOLEN T, JENSEN J, et al. Branched-Chain Amino Acid (BCAA) Metabolism, Insulin Sensitivity (IS), and Liver Fat Response to Exercise Training in Sedentary Prediabetic and Normoglycemic Men. Am Diabetes Assoc; 2018.##Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, et al. Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia. 2015;58(10):2324-35.##White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, et al. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. 2016;5(7):538-51.##She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched chain amino acid (BCAA) metabolism. American Journal of Physiology-Endocrinology and Metabolism. 2017.##Tochikubo O, Nakamura H, Jinzu H, Nagao K, Yoshida H, Kageyama N, et al. Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome. 2016;6(2):e197.##Gettman LR, Ward P, Hagan RD. A comparison of combined running and weight training with circuit weight training. Med Sci Sports Exerc. 1982;14(3):229-34.##Pichon C, Hunter G, Morris M, Bond R, Metz J. Blood pressure and heart rate response and metabolic cost of circuit versus traditional weight training. The Journal of Strength & Conditioning Research. 1996;10(3):153.##Klein BE, Klein R, Lee KE. Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diabetes care. 2002;25(10):1790-4.##Ishii T, Yamakita T, Sato T, Tanaka S, Fujii S. Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes care. 1998;21(8):1353-5.##Gordon B, Benson A, Bird S, Fraser S. Resistance training improves metabolic health in type 2 diabetes: a systematic review. Diabetes research and clinical practice. 2009;83(2):157-75.##Stefanov T, Temelkova-Kurktschiev T, Koehler C, Henkel E, Schaper F, Hanefeld M. Association of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes. Folia medica. 2012;54(2):32-9.##Deldicque L, Atherton P, Patel R, Theisen D, Nielens H, Rennie MJ, et al. Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise. European journal of applied physiology. 2008;104(1):57-65.##Lucotti P, Monti LD, Setola E, Galluccio E, Gatti R, Bosi E, et al. Aerobic and resistance training effects compared to aerobic training alone in obese type 2 diabetic patients on diet treatment. Diabetes research and clinical practice. 2011;94(3):395-403.##Greiwe JS, Kwon G, McDaniel ML, Semenkovich CF. Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. American Journal of Physiology-Endocrinology And Metabolism. 2001;281(3):E466-E71.##Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431(7005):200.##Goffredo M, Santoro N, Tricò D, Giannini C, D’Adamo E, Zhao H, et al. A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease. Nutrients. 2017;9(7):642.##White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, et al. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular metabolism. 2016;5(7):538-51.##Geidenstam N, Magnusson M, Danielsson AP, Gerszten RE, Wang TJ, Reinius LE, et al. Amino acid signatures to evaluate the beneficial effects of weight loss. 2017;2017.##Hanvold SE, Vinknes KJ, Bastani NE, Turner C, Løken EB, Mala T, et al. Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain? 2017:1-9.##