##White LJ, Castellano V. Exercise and brain health—implications for multiple sclerosis. Sports medicine. 2008;38(2):91-100.##Bernardes D, Oliveira-Lima OC, da Silva TV, Faraco CCF, Leite HR, Juliano MA, et al. Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise. Journal of neuroimmunology. 2013;264(1-2):24-34.##Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). British journal of pharmacology. 2011;164(4):1079-106.##Chen C-D, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, et al. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. Journal of Neuroscience. 2013;33(5):1927-39.##Zeldich E, Chen C-D, Avila R, Medicetty S, Abraham CR. The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination. Journal of Molecular Neuroscience. 2015;57(2):185-96.##Greer JM, Pender MP. Myelin proteolipid protein: an effective autoantigen and target of autoimmunity in multiple sclerosis. Journal of autoimmunity. 2008;31(3):281-7.##Degaspari S, Tzanno-Martins CB, Fujihara CK, Zatz R, Branco-Martins JP, Viel TA, et al. Altered KLOTHO and NF-κB-TNF-α signaling are correlated with nephrectomy-induced cognitive impairment in rats. PloS one. 2015;10(5):e0125271.##Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140(6):918-34.##Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future medicinal chemistry. 2012;4(13):1671-9.##King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, et al. Identification of novel small molecules that elevate Klotho expression. Biochemical Journal. 2012;441(1):453-61.##Ji N, Luan J, Hu F, Zhao Y, Lv B, Wang W, et al. Aerobic exercise‑stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney. Experimental and therapeutic medicine. 2018;16(4):3511-7.##Tan S-J, Chu MM, Toussaint ND, Cai MM, Hewitson TD, Holt SG. High-intensity physical exercise increases serum α-klotho levels in healthy volunteers. Journal of circulating biomarkers. 2018;7:1849454418794582.##Aleagha MSE, Siroos B, Ahmadi M, Balood M, Palangi A, Haghighi AN, et al. Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing–remitting multiple sclerosis. Journal of neuroimmunology. 2015;281:5-8.##Aleagha MSE, Harirchian MH, Lavasani S, Javan M, Allameh A. Differential expression of klotho in the brain and spinal cord is associated with total antioxidant capacity in mice with experimental autoimmune encephalomyelitis. Journal of Molecular Neuroscience. 2018;64(4):543-50.##Dalgas U, Stenager E. Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis? Therapeutic advances in neurological disorders. 2012;5(2):81-95.##Briken S, Gold S, Patra S, Vettorazzi E, Harbs D, Tallner A, et al. Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial. Multiple Sclerosis Journal. 2014;20(3):382-90.##Bernardes D, Oliveira-Lima O, da Silva TV, Juliano M, dos Santos DM, Carvalho-Tavares J. Metabolic Alterations in Experimental Autoimmune Encephalomyelitis in Mice: Effects of Prior Physical Exercise. Neurophysiology. 2016;48(2):117-21.##Ferreira JC, Rolim NP, Bartholomeu JB, Gobatto CA, Kokubun E, Brum PC. Maximal lactate steady state in running mice: effect of exercise training. Clinical and Experimental Pharmacology and Physiology. 2007;34(8):760-5.##Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA. Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiology & behavior. 2015;147:78-83.##Castellano V, White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. Journal of the neurological sciences. 2008;269(1):85-91.##Gold SM, Schulz K-H, Hartmann S, Mladek M, Lang UE, Hellweg R, et al. Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. Journal of neuroimmunology. 2003;138(1):99-105.##Barry A, Cronin O, Ryan AM, Sweeney B, Yap SM, O'Toole O, et al. Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology. Frontiers in Physiology. 2016;7:194.##Briken S, Rosenkranz SC, Keminer O, Patra S, Ketels G, Heesen C, et al. Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of neuroimmunology. 2016;299:53-8.##Leavitt V, Cirnigliaro C, Cohen A, Farag A, Brooks M, Wecht J, et al. Aerobic exercise increases hippocampal volume and improves memory in multiple sclerosis: preliminary findings. Neurocase. 2014;20(6):695-7.##Wens I, Broekmans T, Hendriks J, Savelberg H, Hesselink M, Eijnde B. Effects of exercise intensity in experimental autoimmune encephalomyelitis. Journal of Multiple Sclerosis. 2015;2015.##Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, et al. Regulation of skeletal muscle peroxisome proliferator-activated receptor γ expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertension Research. 2004;27(1):61-70.##Muñoz A, Corrêa CL, Lopez-Lopez A, Costa-Besada MA, Diaz-Ruiz C, Labandeira-Garcia JL. Physical exercise improves aging-related changes in angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia nigra. The Journals of Gerontology: Series A. 2018;73(12):1594-601.##Kunert SK, Hartmann H, Haffner D, Leifheit-Nestler M. Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children. Journal of bone and mineral metabolism. 2016:1-12.##Nieves J, Cosman F, Herbert J, Shen V, Lindsay R. High prevalence of vitamin D deficiency and reduced bone mass in multiple sclerosis. Neurology. 1994;44(9):1687-.##Patel D, White L, Lira V, Criswell D. Forced exercise increases muscle mass in eae despite early onset of disability. Physiological research. 2016;65(6):1013.##Rossi S, Furlan R, De Chiara V, Musella A, Giudice TL, Mataluni G, et al. Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis. Neurobiology of disease. 2009;36(1):51-9.##