نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
2 گروه علوم ورزشی، واحد مرودشت، دانشگاه آزاد اسلامی، مرودشت، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Objectives: Lung cancer is related to the reduction of antioxidant function in lung cells. Although it is known that exercise increases the efficiency of the body's antioxidant defense, the effect of swimming training on lung tissue antioxidant enzymes in samples with lung cancer is not well known. Therefore, the aim of the present study was to investigate the effect of 12 weeks of swimming training on lung tissue antioxidant changes in a benzopyrene (BZP) model of lung cancer
Methods: In this experimental study, 12 BALB/c male mice aged 8-10 weeks, weighing 18-22 grams (infected with lung cancer by injection of 100 mg/kg BZP) were divided into lung cancer (LC) and swimming training (ST) groups. Also, 6 mice were considered as healthy control (HC) group. Mice in the training group performed swimming exercises with 2-5% of their body weight for 12 weeks, three sessions a week and each session was 5-38 minutes. 48 hours after the last training session, the lung tissue was used to measure the concentration of superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione (GSH) enzymes. The results were analyzed using one-way analysis of variance with Tukey's post hoc test in SPSS software version 22 and a significance level of 0.05.
Results: The levels of SOD, GPX and GSH in the LC and ST groups were significantly lower than the HC group (P = 0.001). Although the amount of GSH in the ST group was significantly higher than the LC group (P = 0.026), no significant difference was observed in the GPX and SOD levels between the LC and ST groups.
Conclusion: According to the study results, it seems that swimming exercise has different effects on lung tissue antioxidant enzymes in samples with lung cancer. Due to the limited information, it is necessary to conduct more studies in this field.
کلیدواژهها [English]
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