نوع مقاله : مقاله پژوهشی
نویسندگان
گروه تربیت بدنی، دانشگاه آزاد اسلامی واحد اهواز، اهواز، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
The aim of this study was to investigate the effect of eight weeks of aerobic training followed by twelve weeks of high-fat diet on the expression levels of REBC, KLF4 and PPARγ genes in the visceral fat tissue of male Wistar rats. 28 male Wistar rats were divided into two groups of standard diet (n=7) and high fat diet (n=21). The high-fat diet contained 20 g of protein, 20 g of total fat, 48 g of carbohydrate, and 4 g of fiber per 100 g and 5.12 kcal/g. At the end of the twelfth week and after making sure of obesity by evaluating the body composition indices, the rats fed with high-fat diet were randomly divided into three groups. Aerobic exercise was performed for eight weeks and five sessions per week .48 hours after the last training session the rats were anesthetized with an intraperitoneal injection of a combination of ketamine and xylazine and then dissected. The expression level of REBC, KLF4 and PPARγ genes was measured by Real-time PCR method. The results showed that a high-fat diet led to a significant increase in the expression of REBC, KLF4 and PPARγ genes, while eight weeks of aerobic training significantly decreased the expression of REBC, KLF4 and PPARγ genes . According to the results of the present study it is concluded that aerobic exercise can prevent the accumulation of fat in the body by reducing the expression of adipogenesis-stimulating genes and, as a result, the occurrence of obesity and related diseases.
کلیدواژهها [English]
)