تاثیر تمرین هوازی بر سطوح سرمی مولکول‌های چسبان سلولی (ICAM) و مولکول‌های چسبان عروقی (VCAM) در زنان چاق مبتلا به سندرم تخمدان پلی کیستیک

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه تربیت بدنی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران.

2 استاد گروه فیزیولوژی ورزشی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران.

3 استاد گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اراک، اراک، ایران.

4 استادیار گروه تربیت بدنی، دانشکده علوم انسانی، دانشگاه غیر انتفاعی طلوع مهر، قم، ایران.

10.22080/jaep.2024.27071.2187

چکیده

اهداف: زنان مبتلا به سندرم تخمدان پلی کیستیک (PCOS) در معرض خطر افزایش بیماری­های قلبی-عروقی هستند. تمرین ورزشی یک راهکار درمانی برای بهبود عملکرد قلبی و کاهش میزان مرگ و میر در بیماران مختلف است. از این رو پژوهش حاضر با هدف بررسی تاثیر ۱۲ هفته تمرین هوازی بر برخی عوامل عملکرد اندوتلیال عروقی شامل 1-ICAM و 1-VCAM در زنان چاق مبتلا به PCOS انجام شد.
روش مطالعه: سی زن مبتلا به PCOS با  BMIبیش از 9/29 و دامنه سنی 90/3±66/27 سال، به­طور تصادفی به دو گروه تمرین هوازی (۱۵=n) و کنترل (۱۵=n) تقسیم شدند. یک دوره تمرینی 12 هفته­ای برنامۀ تمرین هوازی نظارت شده با شدت متوسط و مدت زمان 150 دقیقه در هفته، شامل 30 دقیقه راه رفتن سریع یا دویدن آهسته مداوم در 5 روز از هفته با شدت 70 تا 85 درصد ضربان قلب بیشینه انجام گرفت، متغیرهـای (ICAM-1) و (VCAM-1) در دو مرحله قبل و 48 ساعت پس از آخرین جلسه تمرین به روش الایزا اندازه گیری شد. از آزمون تحلیل کوواریانس برای تحلیل داده­ها استفاده شد.
یافته ­ها: یافته‌های تحقیق حاضر نشان داد 12 هفته تمرین هوازی موجب کاهش معنادار سطوح سرمی 1-ICAM و 1-VCAM در زنان چاق مبتلا به PCOS شده است (05/0>P).
نتیجه گیری: یافته­ ها نشان داد یک دوره تمرین هوازی، منجر به کاهش سطوح 1-ICAM و 1-VCAM و احتمالاً بهبود عملکرد اندوتلیال عروقی در زنان چاق مبتلا به PCOS شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Aerobic Training on Serum Levels of Cell Adhesion Molecules-1 and Vascular Adhesion Molecules-1 in Obese Women with Polycystic Ovary Syndrome

نویسندگان [English]

  • Niloofar Mosaffa 1
  • Bahram Abedi 2
  • Abbas Saremi 3
  • Abbas Mehranpour 4
1 Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran
2 Department of Physical Education and Sports Science, North Tehran Branch, Islamic Azad University, Tehran, Iran
3 Department of Sports Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran
4 Department of Sports Science, Faculty of Humanities, Tolouemehr University, Qom, Iran
چکیده [English]

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk of cardiovascular diseases. Exercise training is a therapeutic strategy to improve cardiac function and reduce mortality in various patients. Therefore, the present study was conducted to investigate the effect of 12 weeks of aerobic training on some factors of vascular endothelial function including ICAM-1 and VCAM-1in obese women with PCOS.
Methods: Thirty women with PCOS with BMI more than 29.9 and age range of 27.6±3.9 years were randomly divided into two aerobic training groups (n=15) and control (n=15). A 12-week aerobic training program with a duration of 150 minutes per week, including 30 minutes of continuous fast walking or slow jogging on 5 days at an intensity of 70 to 85% of maximum heart rate was performed. The variables ICAM-1 and VCAM-1 were measured before and 48 hours after the last training session by ELISA. Analysis of covariance was used to analyze the data.
 Results: The findings of the present study showed that 12 weeks of aerobic exercise significantly reduced serum levels of ICAM-1and VCAM-1 in obese women with PCOS (P<0.05).
Conclusion: The findings showed that aerobic training led to a decrease in ICAM 1-and VCAM-1 levels and possibly improved vascular endothelial function in obese women with PCOS.

کلیدواژه‌ها [English]

  • Aerobic Training
  • ICAM-1
  • VCAM-1
  • Polycystic Ovary Syndrome
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