نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی، گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران.
2 دانشیار فیزیولوژی ورزشی، گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران.
3 دانشیار فیزیولوژی جانوری، گروه زیست‌شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران.
4 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران.
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Objectives: In Parkinson's disease, due to disruption of the BDNF/TrkB pathway, dopaminergic neurons are damaged and die. The aim of present study was to examine the effect of six weeks high intensity interval swimming training on BDNF/TrkB pathway in Parkinson rat model.
Methods: In this experimental study, fourteen mature Wistar male rats were subjected to Parkinson's disease (PD) through intraperitoneally injection of 5 mg/kg reserpine and then were divided into PD group or training group randomly. Seven healthy rats were assigned to the control group. The rats in the training groups swam 20 times of 30 seconds with 30 seconds of rest between each time, 3 days a week for 6 weeks. After the 6-week intervention, BDNF and TrkB gene expressions were measured in hippocampus.
Results: Data indicated that the BDNF gene expression was lower in the PD group compare to the healthy control and training group (p=0.001 and p=0.001 respectively). No significant differences were observed between healthy control group and training group. For TrkB gene expression also data revealed that this protein gene expression was lower in the PD group compare to the healthy control and training group (p=0.04 and p=0.03 respectively), while no significant differences were observed between healthy control group and training group.
Conclusion: According to study results, it seems that high intensity interval swimming training increases brain neurotrophins content and activity in PD. Therefore, this type of exercise is recommended for future research in Parkinson's patients.
کلیدواژه‌ها [English]
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