نوع مقاله : مقاله پژوهشی
نویسندگان
1 عضو هیات علمی گروه تربیت بدنی دانشگاه آزاد اسلامی شیراز
2 گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
3 گروه زیست‌شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
neurons are damaged and die. The aim of present study was to examine the effect of six weeks high intensity interval swimming training on BDNF/TrkB pathway in Parkinson rat model.
Methods: In this experimental study, fourteen mature Wistar male rats were subjected to Parkinson's disease (PD) through intraperitoneally injection of 5 mg/kg reserpine and then were divided into PD group or training group randomly. Seven healthy rats were assigned to the control group. The rats in the training groups swam 20 times of 30 seconds with 30 seconds of rest between each time, 3 days a week for 6 weeks. After the 6-week intervention, BDNF and TrkB gene expressions were measured in hippocampus. To analyze the results of the tests, one-way ANOVA and Bonferroni post hoc test were run using SPSS-22.
Results: The data indicated that the BDNF gene expression was lower in the PD group compare to the healthy control and training group (p=0.001 and p=0.001 respectively). No significant differences were observed between healthy control group and training group (p=0.4). For TrkB gene expression also data revealed that this protein gene expression was lower in the PD group compare to the healthy control and training group (p=0.04 and p=0.03 respectively), while no significant differences were observed between healthy control group and training group (p=0.9).
Conclusion: According to study results, it seems that high intensity interval swimming training increases brain neurotrophins content and activity in PD. Therefore, this type of exercise is recommended for Parkinson's patients
کلیدواژه‌ها [English]
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