اثر تمرین هوازی بر سطوح سرمی WISP1، TNF-α و شاخص مقاومت به انسولین در مردان چاق مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری تخصصی فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.

2 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران

3 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.

10.22080/jaep.2023.25488.2144

چکیده

اهداف: دیابت نوع دو با افزایش سطح فاکتورهای التهابی سیستمیک همراه می­باشد که موجب اختلال در عملکرد انسولین می­شود. بنابراین هدف از مطالعه حاضر بررسی تأثیر هشت هفته تمرین هوازی بر سطوح سرمی WISP1، فاکتور نکروز دهنده توموری آلفا (TNF-α) و شاخص مقاومت به انسولین (HOMA-IR) در مردان مبتلا به دیابت نوع دو بود.
روش مطالعه: 22 مرد چاق مبتلا به دیابت نوع دو (سن: 9/4±7/35؛ شاخص توده بدن: 35/2± 45/30) به طور داوطلبانه در این تحقیق شرکت نمودند و بر اساس سطح گلوکز خون به دو گروه تمرین و کنترل تقسیم شدند. آزمودنی­های گروه تمرین در هشت هفته تمرینات هوازی با شدت 70 درصد ضربان قلب بیشینه، سه جلسه در هفته و 50-45 دقیقه در هر جلسه شرکت کردند. خون­گیری جهت ارزیابی فاکتورهای خونی مورد بررسی قبل و 48 ساعت بعد از آخرین جلسه تمرین انجام شد. تجزیه و تحلیل آماری با استفاده از آزمون آنالیز واریانس دو طرفه، تی زوجی و همبستگی پیرسون در سطح معنی­داری 05/0≥P انجام شد.
یافته­ ها: هشت هفته تمرینات هوازی منجربه کاهش معنی ­دار سطوح سرمی WISP1 (002/0=P)، TNF-α (001/0>P)، انسولین (001/0=P)، گلوکز (004/0=P)، HOMA-R (001/0=P)، وزن بدن (001/0=P) و شاخص توده بدنی (BMI) (001/0=P) در پس آزمون در مقایسه با پیش­ آزمون گردید. علاوه بر این، تفاوتی معنی ­دار در سطوح سرمی WISP1 (007/0=P)، TNF-α (02/0=P)، انسولین (01/0=P)، HOMA-IR (018/0=P)، وزن بدن (001/0>P) و BMI (001/0>P) بین گروه تجربی در مقایسه با کنترل وجود داشت. همچنین ارتباط معنی داری بین تغییرات غلظت WISP1 بعد از هشت هفته تمرینات هوازی و HOMA-IR وجود داشت (043/0=P).
نتیجه گیری: به نظر می­ رسد تمرینات هوازی از طریق تعدیل سایتوکاین­های پیش التهابی از قبیل WISP1 و TNF-α موجب بهبود مقاومت به انسولین در مردان چاق مبتلا به دیابت نوع دو می­ شود.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of Aerobic Training on Serum Levels of WISP1 and TNF-α and Insulin Resistance in Obese Men with Type 2 Diabetes

نویسندگان [English]

  • Ali Kharghani 1
  • Najme Rezaeian 2
  • Ali Yaghoubi 3
1 Department of Physical Education, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 Department of Physical Education, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
3 Department of Physical Education, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
چکیده [English]

Objectives Type 2 diabetes is associated with an increase in levels of inflammatory factors in the systemic circulation, which causes impaired insulin function. Thus, the aim of this study was to investigate the impact of eight weeks of aerobic training on WISP1, tumor necrosis factor alpha (TNF-α) and insulin resistance index (HOMA-IR) in obese men with type 2 diabetes.
Methods: Twenty-two obese men with type 2 diabetes (Age: 35.7± 4.9, BMI: 30.45± 2.35) volunteered to participate in the study and divided into two groups of training and control based on their fasting blood glucose levels. Subjects in training group performed eight weeks of aerobic training at intensity of 70 percent of maximum heart rate, three sessions per week and 45-50 minutes per session. Blood samples were collected before and 48 hours after training protocol to measure the blood factors assessed. Statistical analysis was done by two way analysis of variance, paired t-test and Pearson correlation at significant level of P<0.05.
Results: Eight weeks of aerobic training resulted in significant decreases in the serum levels of WISP1 (P=0.002), TNF-α (P<0.001) and insulin (P=0.001), fasting blood glucose (P=0.004), HOMA-IR (P=0.001), body weight (P<0.001), and body mass index (BMI) (P<0.001) in post-test compared to the pre-test . Moreover, there existed significant differences between training group compared to control group for serum levels of WISP1 (P=0.007), TNF-α (P=0.02) and insulin, (P=0.01), HOMA-IR (P=0.018), body weight (P<0.001) and BMI (P<0.001). Additionally, there were significant correlation between changes in serum levels of WISP1 following eight weeks of aerobic training and HOMA-IR (P=0.043).
Conclusion: It seems that aerobic training improves insulin resistance in obese men with type 2 diabetes through modulating pro-inflammatory cytokines such as WISP1 and TNF-α.

کلیدواژه‌ها [English]

  • AerobicTraining
  • Inflammation
  • Diabetes
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