The effect of endurance training on Fibroblast growth factor 23 and Sclerostin in women with chronic kidney disease

Authors

1 Faculty of Physical Education and Sports Sciences, Shahrood University of technology, Shahrood, Iran

2 2. Assistant Professor of Exercise Physiology, Faculty of Physical Education and sport sciences, Shahrood University of Technology, Semnan, Iran.

10.22080/jaep.2026.30481.2238

Abstract

Objectives: Bone mineral density disorder is a very common problem in patients with chronic kidney disease. The present study aimed to investigate the effect of endurance training on fibroblast growth factor 23 and sclerostin in women with chronic kidney disease.
Methods: The present study is a semi-experimental study with a pre-test-post-test and laboratory design. The statistical population of the study was 34 women with chronic kidney disease in Shahrood city, who were classified as 3 to 5. The Subjects were divided into two endurance training and control groups. The experimental group performed aerobic training for 12 weeks, 3 sessions per week, and during this period the control group continued their daily activities. At the beginning and end of the study, serum levels of fibroblast growth factor 23 and sclerostin were measured and evaluated. For statistical analysis, paired t-test was used for intragroup comparison and independent t-test was used for intergroup comparison.
Results: The findings of the present study showed that the amount of fibroblast growth factor 23 and sclerostin in the exercise group was significantly reduced (P=0.03, P=0.008). Also, the results showed that there was a significant difference between the exercise and control groups in the post-test in the amount of fibroblast growth factor 23 and sclerostin (P=0.04, P=0.009). Conclusion: According to the results of the present study, it seems that endurance training plays a role in reducing mineral density disorders mediated by fibroblast growth factor 23 and sclerostin in chronic kidney disease patients.

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History

  • Receive Date: 09 November 2025
  • Revise Date: 04 January 2026
  • Accept Date: 02 February 2026

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