Department of Exercise Physiology, Faculty of Sport Sciences, Shahrood University of Technology, Shahrood, Iran
10.22080/jaep.2026.30481.2238
Abstract
Objectives: Bone mineral density disorders occur with changes in the levels of fibroblast growth factor 23 (FGF-23) and sclerostin in people with chronic kidney disease. Exercise training seems to have a positive effect on bone mineral density. The aim of the present study was to investigate the effect of endurance training on FGF-23 and sclerostin in women with chronic kidney disease. Methods: The present study was a semi-experimental study with a pre-test-post-test design. The statistical population of the study was 32 women with chronic kidney disease, who were classified as 3 to 5. The Subjects were divided into two endurance training and control groups. The experimental group performed aerobic training for 12 weeks, 3 sessions per week, and during this period the control group continued their daily activities. At the beginning and end of the study, serum levels of fibroblast growth factor 23 and sclerostin were measured and evaluated. Data were analyzed using analysis of covariance (ANCOVA). Results: The training program resulted in significant reductions in serum FGF-23 and sclerostin levels in the experimental group compared with the control group (p < 0.05). Conclusion: According to the results of the present study, it seems that endurance training plays a role in reducing mineral density disorders mediated by fibroblast growth factor 23 and sclerostin in chronic kidney disease patients.
Mohammadian, F. , Vosadi, E. , & Donyaei, A. (2025). The Effect of Endurance Training on Fibroblast Growth Factor 23 and Sclerostin in Women with Chronic Kidney Disease. Journal of Applied Exercise Physiology, 21(41), 81-92. doi: 10.22080/jaep.2026.30481.2238
MLA
Fatemeh Mohammadian; Elham Vosadi; Adel Donyaei. "The Effect of Endurance Training on Fibroblast Growth Factor 23 and Sclerostin in Women with Chronic Kidney Disease", Journal of Applied Exercise Physiology, 21, 41, 2025, 81-92. doi: 10.22080/jaep.2026.30481.2238
HARVARD
Mohammadian, F., Vosadi, E., Donyaei, A. (2025). 'The Effect of Endurance Training on Fibroblast Growth Factor 23 and Sclerostin in Women with Chronic Kidney Disease', Journal of Applied Exercise Physiology, 21(41), pp. 81-92. doi: 10.22080/jaep.2026.30481.2238
CHICAGO
F. Mohammadian , E. Vosadi and A. Donyaei, "The Effect of Endurance Training on Fibroblast Growth Factor 23 and Sclerostin in Women with Chronic Kidney Disease," Journal of Applied Exercise Physiology, 21 41 (2025): 81-92, doi: 10.22080/jaep.2026.30481.2238
VANCOUVER
Mohammadian, F., Vosadi, E., Donyaei, A. The Effect of Endurance Training on Fibroblast Growth Factor 23 and Sclerostin in Women with Chronic Kidney Disease. Journal of Applied Exercise Physiology, 2025; 21(41): 81-92. doi: 10.22080/jaep.2026.30481.2238
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