Department of Exercise Physiology, Faculty of Literature and Human Sciences, Shahrekord University, Shahrekord, Iran.
10.22080/jaep.2026.30293.2235
Abstract
Objectives: Overweight and obesity are associated with adverse metabolic alterations, including elevated leptin levels, hyperglycemia, insulin resistance, and activation of inflammatory pathways. These alterations substantially increase the risk of chronic diseases, particularly type 2 diabetes and cardiovascular disorders. In recent years, exercise interventions have been recognized as effective non-pharmacological strategies for managing metabolic and inflammatory dysfunctions. This study aimed to investigate the effects of combined high-intensity interval training (HIIT) and resistance exercise on metabolic and inflammatory markers in overweight men. Methods: In this quasi-experimental study, 30 overweight men were recruited using convenience sampling and randomly assigned to experimental and control groups. The experimental group completed a 12-week combined HIIT and resistance training program (three sessions per week, 45 minutes per session), while the control group received no intervention. Outcome measures included serum leptin, fasting glucose, insulin resistance assessed by the homeostasis model assessment (HOMA-IR), C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Data were analyzed using multivariate analysis of covariance. Results: The combined training program resulted in significant reductions in serum leptin, fasting glucose, insulin resistance, CRP, IL-6, and TNF-α levels in the experimental group compared with the control group (p < 0.05). In addition, significant improvements in body composition were observed following the intervention. Conclusion: The findings suggest that combined high-intensity interval and resistance training is an effective non-pharmacological approach for improving metabolic profiles and reducing systemic inflammation in overweight men.
Hosseini, S. , Ghafari, M. , & Azamian Jazi, A. (2025). Combination of High-Intensity Interval Training and Resistance Training as a Non-Pharmacological Strategy to Improve Metabolic and Inflammatory Indices in Overweight Men. Journal of Applied Exercise Physiology, 21(41), 65-79. doi: 10.22080/jaep.2026.30293.2235
MLA
Saman Hosseini; Mahdi Ghafari; Akbar Azamian Jazi. "Combination of High-Intensity Interval Training and Resistance Training as a Non-Pharmacological Strategy to Improve Metabolic and Inflammatory Indices in Overweight Men", Journal of Applied Exercise Physiology, 21, 41, 2025, 65-79. doi: 10.22080/jaep.2026.30293.2235
HARVARD
Hosseini, S., Ghafari, M., Azamian Jazi, A. (2025). 'Combination of High-Intensity Interval Training and Resistance Training as a Non-Pharmacological Strategy to Improve Metabolic and Inflammatory Indices in Overweight Men', Journal of Applied Exercise Physiology, 21(41), pp. 65-79. doi: 10.22080/jaep.2026.30293.2235
CHICAGO
S. Hosseini , M. Ghafari and A. Azamian Jazi, "Combination of High-Intensity Interval Training and Resistance Training as a Non-Pharmacological Strategy to Improve Metabolic and Inflammatory Indices in Overweight Men," Journal of Applied Exercise Physiology, 21 41 (2025): 65-79, doi: 10.22080/jaep.2026.30293.2235
VANCOUVER
Hosseini, S., Ghafari, M., Azamian Jazi, A. Combination of High-Intensity Interval Training and Resistance Training as a Non-Pharmacological Strategy to Improve Metabolic and Inflammatory Indices in Overweight Men. Journal of Applied Exercise Physiology, 2025; 21(41): 65-79. doi: 10.22080/jaep.2026.30293.2235
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