The Effect of Aerobic Training on Serum Levels of Cell Adhesion Molecules-1 and Vascular Adhesion Molecules-1 in Obese Women with Polycystic Ovary Syndrome

Document Type : Research Paper

Authors

1 Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran

2 Department of Physical Education and Sports Science, North Tehran Branch, Islamic Azad University, Tehran, Iran

3 Department of Sports Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran

4 Department of Sports Science, Faculty of Humanities, Tolouemehr University, Qom, Iran

10.22080/jaep.2024.27071.2187

Abstract

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk of cardiovascular diseases. Exercise training is a therapeutic strategy to improve cardiac function and reduce mortality in various patients. Therefore, the present study was conducted to investigate the effect of 12 weeks of aerobic training on some factors of vascular endothelial function including ICAM-1 and VCAM-1in obese women with PCOS.
Methods: Thirty women with PCOS with BMI more than 29.9 and age range of 27.6±3.9 years were randomly divided into two aerobic training groups (n=15) and control (n=15). A 12-week aerobic training program with a duration of 150 minutes per week, including 30 minutes of continuous fast walking or slow jogging on 5 days at an intensity of 70 to 85% of maximum heart rate was performed. The variables ICAM-1 and VCAM-1 were measured before and 48 hours after the last training session by ELISA. Analysis of covariance was used to analyze the data.
 Results: The findings of the present study showed that 12 weeks of aerobic exercise significantly reduced serum levels of ICAM-1and VCAM-1 in obese women with PCOS (P<0.05).
Conclusion: The findings showed that aerobic training led to a decrease in ICAM 1-and VCAM-1 levels and possibly improved vascular endothelial function in obese women with PCOS.

Keywords

Journal of Applied Exercise Physiology
Volume 19, Issue 38
February 2024
Pages 55-67

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History

  • Receive Date: 21 May 2024
  • Revise Date: 02 August 2024
  • Accept Date: 12 August 2024

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