The Effect of Six Weeks High Intensity Interval Swimming Training on BDNF/Trkb Pathway in Parkinson Rat Model

Document Type : Research Paper

Authors

1 Department of ٍٍ Exercise Physiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran

2 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran

3 Department of Exercise Physiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran

10.22080/jaep.2024.26603.2172

Abstract

Objectives: In Parkinson's disease, due to disruption of the BDNF/TrkB pathway, dopaminergic neurons are damaged and die. The aim of present study was to examine the effect of six weeks high intensity interval swimming training on BDNF/TrkB pathway in Parkinson rat model.
Methods: In this experimental study, fourteen mature Wistar male rats were subjected to Parkinson's disease (PD) through intraperitoneally injection of 5 mg/kg reserpine and then were divided into PD group or training group randomly. Seven healthy rats were assigned to the control group. The rats in the training groups swam 20 times of 30 seconds with 30 seconds of rest between each time, 3 days a week for 6 weeks. After the 6-week intervention, BDNF and TrkB gene expressions were measured in hippocampus.
Results: Data indicated that the BDNF gene expression was lower in the PD group compare to the healthy control and training group (p=0.001 and p=0.001 respectively). No significant differences were observed between healthy control group and training group. For TrkB gene expression also data revealed that this protein gene expression was lower in the PD group compare to the healthy control and training group (p=0.04 and p=0.03 respectively), while no significant differences were observed between healthy control group and training group.
Conclusion: According to study results, it seems that high intensity interval swimming training increases brain neurotrophins content and activity in PD. Therefore, this type of exercise is recommended for future research in Parkinson's patients.

Keywords

Journal of Applied Exercise Physiology
Volume 19, Issue 37
March 2023
Pages 63-75

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History

  • Receive Date: 16 January 2024
  • Revise Date: 04 February 2024
  • Accept Date: 17 February 2024

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