Document Type : Research Paper
Authors
1
Department of Exercise Physiology, Faculty of Sport Sciences,, University of Mazandaran, Babolsar, Iran
2
Department of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, Iran.
3
Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran.
4
Department of Exercise Physiology, Faculty of Sport Sciences,, University of Mazandaran, Babolsar, Iran,
10.22080/jaep.2024.26264.2166
Abstract
Objectives: The purpose of this study was to determine whether moderate and high-intensity endurance exercise combined with safflower seed oil is effective in treating non-alcoholic fatty liver disease (NAFLD).
Methods: We divided 35 male rats into seven groups, including: healthy control group (HC), fatty liver control group (FC), fatty liver plus moderate exercise training (FME), fatty liver plus high intensity exercise training (FHE), fatty liver plus safflower seed oil (5 mg/kg of body weight by gavage) (FO), fatty liver plus oil plus moderate exercise training (FOME) group and fat liver plus oil plus high exercise training (FOHE). The induction of NAFLD was accomplished by injecting dexamethasone (DEX:8mg/kg). Training groups ran on the treadmill five days per week at high and medium intensities at the same distance for 10 weeks. Lipid profile and glucose levels in serum along with liver expression of PGC1α and PPARα genes were measured.
Results: The results showed that DEX-induced NAFLD caused a significant decrease in PGC1α gene expression and an increase in serum glucose and TG levels in the FC group compared to the HC group. In addition, PGC1α gene expression was significantly increased in the FHE group compared to the FC, FOME and FOHE groups. A significant decrease was observed in serum glucose and TC levels in the FME, FHE, FOME and FOHE groups compared to the FC group. Also, a significant decrease in the TG level was observed in the FOHE group compared to the FC, FO and FOME groups.
Conclusion: The results showed that only high-intensity endurance training can increase the expression of PGC1α gene, and due to the key role in the transcription of factors involved in fatty acid oxidation and glucose homeostasis in the liver, high-intensity training can be more effective in improving fatty liver disease than moderate-intensity training.
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