The effect of 12 weeks of resistance training on serum copeptin levels, hs-CRP, and insulin resistance in elderly women

Document Type : Research Paper

Authors

Department of Sport Sciences, Faculty of Letters and Humanities, Shahrekord University, Shahrekord, Iran.

10.22080/jaep.2023.25799.2150

Abstract

Objectives: Increased copeptin level is associated with increased inflammation and insulin resistance, and its concentration is significantly higher in the elderly than in the young. Therefore, the present study aimed to investigate the effect of 12 weeks of elastic band resistance training (EBRT) on the serum levels of copeptin, hs-CRP, and insulin resistance.
Methods: Twenty-eight elderly women (age 74.04±4.69 years and body mass index 28.21±3.35 kg/m2) were selected based on the inclusion criteria and randomly assigned into one of two groups, exercise (n = 14) or control (n = 14) to participate in a 12-week (3d/wk) supervised EBRT. The exercise intensity was checked using the Borg scale at points 12 to 14. Pre-test measurements were taken before starting the training protocol, and post-test measurements were performed 48 hours after the last training session. Data were analyzed using two-way repeated-measures ANOVA.
Results: After 12 weeks of EBRT, no significant difference was observed in the anthropometric indices other than body fat percentage. A greater and significant decrease in body fat percentage was observed in the training group (p=0.023). Serum glucose levels did not change significantly, but serum insulin levels (p=0.035) and insulin resistance (p=0.045) decreased significantly. No significant change in serum levels of copeptin was observed after 12 weeks of training, but the reduction of hs-CRP serum levels was significant (p=0.037).
Conclusion: Although the serum levels of copeptin did not change significantly after 12 weeks of EBRT, it seems that the reduction of insulin resistance and hs-CRP could be due to body composition improvement and indicate reduced inflammation and improved health in elderly women.

Keywords


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