The effect of endurance training and Anvillea garcinii extract consumption on liver and kidney functional indices in rats fed with high cholesterol diet

Document Type : Research Paper

Authors

1 Department of Exercise Physiology, Payame Noor University, Tehran Iran.

2 Department of Biology, Faculty of Basic Sciences, Payame Noor University, Tehran, Iran.

10.22080/jaep.2022.23288.2096

Abstract

Background & Purpose: Obesity and its complications such as high blood pressure, fatty liver, type 2 diabetes and kidney failure are considered to be the main life-threatening cases. Therefore, the aim of this study was to investigate of eight weeks of endurance training and consumption of Anvillea garcinii extract on liver and kidney functional indices in rats fed with high cholesterol diet.
Methodology: 35 male Wistar rats randomly divided into five groups of seven; Normal control (CON), hypercholesterolemic control (HC), alcoholic extract of anvil plant (Ext), exercise training (E) and exercise training combined with anvil extract (Ext+E). The extract of anvil plant in the amount of 100 mg per kilogram of the weight of the rat was given by gavage three days a week for 8 weeks. The training groups ran for 30 minutes on the treadmill for 5 days a week for eight weeks with an intensity of 65-70% of VO2max. The biochemical variables of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, albumin, and bilirubin and total protein of blood serum were measured 24 hours after the last training session.
Results: The results of the one-way analysis of variance test showed that there is a significant difference between the groups between the levels of cholesterol, AST, ALT, bilirubin, creatinine, albumin, bilirubin and total protein (P≤0.05). The results of Tukey's post hoc test showed that there is a significant difference in AST values ​​between the (HC) group and the (E) group (p=0.026). Also, there was a significant difference between the (E) group and (Ext+E) (p=0.027). The amount of ALT in (Ext+E) group was significantly increased compared to (E) group (p=0.006) and compared to (HC) group (p=0.0001). The amount of total protein in the (E) and (Ext+E) groups compared to the (HC) group were significantly increased (p≤0.05). The amount of albumin, bilirubin, and creatinine in the (Ext+E) group was significantly higher than the (HC) (p≤0.05).
Conclusion: The findings of this research showed that the training method and the amount of anvil extract used in this research does not affect the level of kidney and liver function. It is suggested to investigate different doses of this plant in future studies. 

Keywords


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