The effect of six weeks of high intense intermittent training on the expression of P53 and SRF angiogenesis factors in tumor tissue of female mice with breast cancer

Document Type : Research Paper

Authors

1 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran Kish International Campus, Kish, Iran

2 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences,University of Tehran,Tehran, Iran

10.22080/jaep.2021.20809.2016

Abstract

Background and Purpose: Breast cancer causes death in women. Angiogenesis plays role in tumor development and metastasis. The effect of exercise on tumor tissue angiogenesis is not fully understood. Therefore, the aim of this study was to investigate the therapeutic effects of high intense intermittent exercise on the expression of angiogenesis factors, in breast cancer tumor tissue of laboratory mice.
Methodology: Sixteen C-balb mice were randomly divided into two groups of control (Sedentary-tumor) and high intense intermittent training-tumor (HIIT-Tumor). After getting acquainted with the laboratory environment, mice were hypodermically infused by tumor cells. After two weeks, exercise capacity test was performed on training group. Then, a six weeks exercise protocol, three sessions per week, with two minutes running and two minutes of rest, was performed. 48 hours after the last training session, the mice were anesthetized and the tumor tissues were isolated. Gene expression was analysed by Genex Software, version 6.1 (P≥0/01).
Results: This study showed that HIIT training decreased SRF by 5.27 times and increased P53 by 5.97 times in the training group, compared to the control group.
Conclusion: It seems that HIIT training, by decreasing SRF and increasing P53 can suppress the tumor and possibly prevent cancer progression.

Keywords


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