Effect of aerobic exercise on vascular endothelial growth factor-B (VEGF-B) gene expression and total tissue antioxidant status (TAS) in diabetic rats

Document Type : Research Paper

Authors

1 Department of Physical Education and Sport Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

2 Department of Exercise Physiology, Sport Science Faculty, Razi University, Kermanshah, Iran

3 Department of Corrective Exercise, Kermanshah branch, Islamic Azad University, Kermanshah, Iran

4 Department of Physical Education and Sport Science, Abadan Branch, Islamic Azad University, Kermanshah, Iran

10.22080/jaep.2021.20280.1996

Abstract

Background and Purpose: Diabetes causes cardiovascular disorders and coronary artery disease or systemic hypertension. Therefore, the aim of the present study was to evaluate the effect of aerobic exercise on vascular endothelial growth factor-B (VEGF-B) gene expression and the amount of total antioxidant status (TAS) of cardiac tissue in diabetic male rats.
Methodology: This experimental study was performed on 30 adult male Wistar rats and divided into 3 groups of Diabetic training, Diabetic control and healthy control (n = 10). Diabetes was induced by a single dose of streptozotocin (45 mg/kg). The exercise program consisted of 6 weeks of treadmill training. 24 hours after of the last training session, cardiac tissue samples were extracted to measure VEGF-B gene expression and TAS. One-way ANOVA and LSD test with statistical level of (P˂0.05) were used to compare between groups differences.
Results: Results showed that after one period of endurance training there was a significant increase in VEGF-B gene expression and TAS in the DT group compared to CD group (P = 0.001). There was no significant difference (P = 0.364) in VEGF-B gene expression, also a significant difference (P = 0.033) was in antioxidant status in DT and HC groups.
Conclusion: It seems that endurance training has a positive effect on VEGF-B and TAS of in the heart of diabetic rats.

Keywords


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