Effect of 12 Weeks of Concurrent Training with Caffeine Supplementation on Selected Adipokines and Insulin Resistance in Obese Postmenopausal Women

Document Type : Research Paper

Authors

1 Department of Physical Education and Sport Sciences, East Tehran branch, Islamic Azad University, Tehran, Iran,

2 Department of Physical Education and Sport Sciences, East Tehran branch, Islamic Azad University, Tehran, Iran

Abstract

Background and Purpose: Adipose tissue is known as an endocrine tissue that secretes a large number of adipokines. In addition to regulating fat metabolism, these adipokines play an important role in pathological and physiological processes The aim of this study was to determine the effect of 12 weeks of Concurrent training with caffeine supplementation on C1q/TNF-Related Protein3, C1q/TNF-related protein 9، Adipoline, Mayonctin and insulin resistance in postmenopausal women.
Methodology: In this quasi-experimental study 44 postmenopausal women (46-58 years) were selected and divided in to Four groups (Control, Caffeine, training, training + Caffeine.Twelve weeks training, 3 sessions per week included continuous aerobic exercises (20 min, 65-75% of HRR), and circular resistance training (10 stations with 70% 1RM). The aerobic training included 20 min duration with 65-75% HRR per session and the resistance training program included 10 stationary exercise as did circular with 70% 1RM.6 milligrams of caffeine per kilogram of body weight (2 to 3 mg) was given orally to supplemental groups.
Results: The results showed a significant increase in CTRP-12, CTRP-15 and significantly reduced insulin resistance in obese postmenopausal women. CTRP-3 and CTRP-9 not change significantly.
Conclusion: 12 weeks of Concurrent training with caffeine consumption can be an effective factor for optimal changes in CTRP-12, CTRP-15 and insulin resistance in obese postmenopausal women.

Keywords


##Wang Q, Ferreira DLS, Nelson SM, Sattar N, Ala-Korpela M, Lawlor DA. Metabolic characterization of menopause: cross-sectional and longitudinal evidence. BMC medicine. 2018;16(1):17-28.##Yang Y LY, Ma Z, Jiang S, Fan C, Hu W, et al. A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection. Progress in lipid research. 2016;64:170-7.##Lei X, Li Q, Rodriguez S, Tan SY, Seldin MM, McLenithan JC, et al. Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. American Journal of Physiology-Endocrinology and Metabolism. 2015;308(9):792-804.##Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, et al. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012;61(11):2776-86.##Li X, Jiang L, Yang M, Wu Y-w, Sun S-x, SunJ-z. CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocrine journal. 2014:EJ14-0161.##Wolf R, Steele KE, Peterson LA, Zeng X, Jaffe AE, Schweitzer MA, et al. C1q/TNF-related protein-9 (CTRP9) levels are associated with obesity and decrease following weight loss surgery. The Journal of Clinical Endocrinology & Metabolism. 2016;101(5):2211-7.##Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang, MJ, Baldeviano GC, et al. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. Journal of Biological Chemistry. 2012;287(13):10301-15.##Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, et al. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. Journal of Biological Chemistry. 2011;286(40):34552-8.##Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 2012;125(5):3159-69.##Wong G, Krawczyk SA, Kitidis-Mitrokostas C, Ge G, Spooner E, Hug C, et al. dentification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. The FASEB Journal. 2009;23(1):241-58.##Thong F, Derave W, Kiens B, GrahamTE, Ursø B, Wojtaszewski JF, et al. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes. 2002;51(3):583-90.##Laurent D, Petersen KF, Russell RR, Cline GW, Shulman GI. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. American Journal of Physiology-Endocrinology And Metabolism. 1998;274(1):130-8.##Egawa T, Hamada T, Kameda N, Karaike K, Ma X, Masuda S, et al. Caffeine acutely activates 5′ adenosine monophosphate–activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism. 2009;58(11):1609-17.##Berggren J, Hulver MW, Houmard JA. Fat as an endocrine organ: influence of exercise. Journal of Applied Physiology. 2005; 99(2):757-64.##You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, et al. Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. Obesity. 2014;22(7):1679-84.##Choi H, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, et al. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013;36(10):3321-7.##Li S, Holm K, Gulanick M, Lanuza D, Penckofer S. The relationship between physical activity and perimenopause. Health Care for Women International. 1999;20(2):163-78.##Ebrahim k, bassami m, kolahdoz s, karimnia saheb v. The Effects of Circuit Resistance Exercise on Fat and Carbohydrate Metabolism During Endurance Exercise in Overweight Men. Iranian Journal of Endocrinology and Metabolism. 2012;14(3):257-66.##Assarzade Noushabadi M, Abedi B. Effects of combination training on insulin resistance index and some inflammatory markers in inactive men. The Horizon of Medical Sciences. 2012; 18 (3):95-105.##Schubert M, Hall S, Leveritt M, Grant G, Sabapathy S, Desbrow B. Caffeine consumption around an exercise bout: effects on energy expenditure, energy intake, and exercise enjoyment. Journal of Applied Physiology. 2014;117(7):745-54.##Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr.1978; 40: 497-504.##Singh B, Arora S, Goswami B, Mallika V. Metabolic  syndrome:  A  review  of  emerging markers   and   management.   Diabetes   & Metabolic  Syndrome.  Clinical  Research  & Reviews. 2009 ;3(4) :240-54.##Kim JY, Min JY, Baek JM, Ahn SJ, Jun HY, Yoon KH, et al. CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone. 2015; 79: 242-51.##Azali Alamdari K, Ghorbanian B. Effect of aerobic training on serum adiponectin and ctrp-3 in males with metabolic syndrome. Iranian Journal of Endocrinology and Metabolism. 2017; 18: 368-77.[ Persian]##Hasegawa N, Fujie S, Horii N, Uchida M, Kurihara T, Sanada K, et al. Aerobic exercise traininginduced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Regul Integr Comp Physiol . 2018; 314: R94-R101.##Weisberg SP, Desai M, Rosenbaum M. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–808.##Zhang X, Yang T, Ye Y, Shan JH, Yin ZM, et al. Chlorogenic acid protects mice against lipopolysaccharide induced acute lung injury. Inj Int J Care Inj. 2010;41:746–52.##Fredholm BB. Caffeine and the biological role of adenosine receptors. J Alzheimers Dis. 2009;4.##Rahmatollahi M, Ravasi A, Soori R. Effect of 8 Weeks of Low-Intensity Continuous Training on Plasma Adipolin, Insulin Resistance, and Weight of Fatty FatFilled Rats. Adv Obes Weight Manag Control. 2017; 7(5): 00211.[ Persian]##Soori R, Salehian O. Effects of high and low intensity endurance training on levels of leptin, cortisol, testosterone, growth hormone, and insulin res-istance index in sedentary obese men. J Sport Biomotor Sci. 2012;6:17-28.[ Persian]##Lau DC, Morrison KM, Hramiak IM, Sharma AM, Ur E. Obesity Canada Clinical Practice Guidelines Expert Panel. 2006 Canadian clinical practi-ce guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ. 2007;176(1-13).##Pournjbar M, Arabnejad N, Naderi Pourkh, Rafiei F. The effect of aerobic exercise on serum mayonectin and insulin resistance in obese and overweight women. of Medical and Life Journal. 2018; 11 (4): 381-6. [ Persian]##Mirzaei M. The effect of four weeks of intense intermittent exercise with restricted blood flow (BFR) on serum levels of mayonectin in young men active. Master Thesis in Sports Physiology, Tarbiat Modares University. 2018. [ Persian]##Gamas MP, Seiça R. Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk. Journal of diabetes research. 2015.##Dasilva LA, Medeiros TE, Osiecki R, Garcia Michel R, Snak AL, et al. Caffeine modifies blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes. Colombia Médica. 2014;45(2):72-6.##