Effect of HIT and Supplementation of Arginine under Isoenergetic Conditions on PYY3-36 Signal and Anthropometric Indices in obese boys

Document Type : Research Paper

Authors

1 Ph.D. student of Biochemistry and Sport Metabolism, Faculty of sport sciences, Ferdowsi University of Mashhad

2 associated professor/ ferdowsi university

3 - Professor of Sport Physiology, Faculty of sport sciences, Ferdowsi University of Mashhad

4 Associate Professor of Sport Physiology, Faculty of sport sciences, Ferdowsi University of Mashhad

5 Assistant Professor of Sport Physiology, Faculty of sport sciences, Ferdowsi University of Mashhad

Abstract

Abstract

Background&Purpose.physical training appropriate selection and nutritional considerations is an important factor in changing the lifestyle of obese Adolescent and Effective Index in control and treatment of obesity.The purpose of this study was to determine the effect of eight weeks of HIT and supplementation of arginine under isoenergetic conditions on PYY3-36 signal and anthropometric indices in obese boys. Methodology. In isoenergetic conditions, 20 obese adolescents were randomly divided into two groups including: 1) HIT and placebo (C, n=10) and HIT with supplementation of arginine (T, n=10). Before Intervention exercise Protocol and 48 hours after the last exercise session, hormonal levels of PYY3-36 in blood and Anthropometric Indices were measured. For Investigation the differences between intra-and intergroup, Independent and independent Student was used. Results.The results showed that intra-and intergroup weight loss was significant (p≤0.05). The decrease in body mass index in both groups was significant (p≤0.05), but the intra group changes were not significant(P ≥0.05). Body fat percentage changes were not significant in both groups (P ≥0.05). The results showed that there was no significant difference between PYY3-36 peptide compared to baseline levels among and between in C and T groups(P ≥0.05). Conclusion: Despite some contradictions, however, arginine supplementation along with HIT seems to be an effective approach in weight management for obse boys, Although, determining the mechanism and nature of the effect of these exercises on PYY3-36 requires further studies.

Keywords

References

##Ogden, C.L., Carroll, M.D., Kit, B.K., and Flegal, K.M. 2014. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA, 311(8): 806–814.doi:10.1001/jama.2014.732. PMID:24570244.##WHO. 2014. Global strategy on diet, physical activity, and health: childhood overweight and obesity. http://www.who.int/dietphysicalactivity/childhood/en/. [Accessed 20 November 2014.]##Burns, S.F., and Arslanian, S.A. 2009. Waist circumference, atherogenic lipoproteins, and vascular smooth muscle biomarkers in children. J. Clin. Endocrinol. Metab. 94(12): 4914–4922. doi:10.1210/jc.2009-1301. PMID:19846736.##Lee, S., Bacha, F., Gungor, N., and Arslanian, S. 2008. Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J. Pediatr. 152(2): 177–184.e3. doi:10.1016/j.jpeds.2007.07.053. PMID:18206686.##Mushtaq MU, Gull S, Abdullah HM, Shahid U, Shad MA, Akram J. Waist circumference, waist-hip ratio and waist-height ratio percentiles and central obesity among Pakistani children aged five to twelve years. BMC Pediatr. 2011; 11: 105.##Han, J.C., Lawlor, D.A., and Kimm, S.Y.S. 2010. Childhood obesity. Lancet, 375(9727): 1737–1748. doi:10.1016/S0140-6736(10)60171-7. PMID:20451244.##Ravussin, E., Smith, S.R., Mitchell, J.A., Shringarpure, R., Shan, K., Maier, H., et al. 2009. Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring), 17(9): 1736–1743. doi:10.1038/oby.2009.184.##Horner, K., Lee, S. 2015. Appetite-related peptides in childhood and adolescence: role of ghrelin, PYY, and GLP-1. Appl. Physiol. Nutr. Metab. 40: 1–11 (2015) dx.doi.org/10.1139/apnm-2015-0050.##Foster-Schubert, K.E., Overduin, J., Prudom, C.E., Liu, J., Callahan, H.S., Gaylinn, B.D., et al. 2008. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J. Clin. Endocrinol. Metab. 93(5): 1971–1979. doi:10.1210/jc.2007-2289. PMID:18198223.##Gibbons, C., Caudwell, P., Finlayson, G., Webb, D.-L., Hellström, P.M., Naslund, E., and Blundell, J.E. 2013. Comparison of postprandial profiles of ghrelin, active GLP-1, and total PYY to meals varying in fat and carbohydrate and their association with hunger and the phases of satiety. J. Clin. Endocrinol. Metab. 98(5): E847–E855. doi:10.1210/jc.2012-3835. PMID:23509106.##Jaak Jurimae, Toiv Jurimae. Ghrelin Responses to Acute Exercise and Training. Endocrinology of Physical Activity and Sport Contemporary Endocrinology 2013; 207-19.##Broom DR, Batterham RL, King JA, Stensel DJ. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. Am J Physiol Regul Integr Comp Physiol 2009; 296: R29-35.##Ueda SY, Yoshikawa T, Katsura Y, Usui T, Fujimoto S.Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise. J Endocrinol 2009; 203: 357-64.##Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol 2009; 587: 19-25.##Ueno H, Yamaguchi H, Mizuta M, Nakazato M. The role of PYY in feeding regulation. Regul Pept 2008; 145: 12-6.##Prado WL, Lofrano MC, Cardel M, Balagopal P, Oyama LM, Gomes PP, Andrade M, Freitas C RM, Hill JO. Effect of a 12-Week Low vs. High Intensity Aerobic Exercise Training on Appetite-Regulating Hormones in Obese Adolescents: A Randomized Exercise Intervention Study. Pediatric Exercise Science, 2015; 27, 510 517.doi:10.1123/pes.2015-0018. Human Kinetics, Inc.##Gueugnon, C., Mougin, F., Nguyen, N., Bouhaddi, M., Nicolet-Guénat, M., and Dumoulin,G.2012.Ghrelin and PYY levels in adolescents with severe obesity: Effects of weight loss induced by long-term exercise training and modified food habits. Eur. J. Appl. Physiol. 112(5): 1797–1805. PMID:21909986.##Jones, T.E., Basilio, J.L., Brophy, P.M., McCammon, M.R., and Hickner, R.C. 2009. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity, 17(6): 1189–1195. PMID:19247279.##Roth, C.L., Enriori, P.J., Harz, K., Woelfle, J., Cowley, M.A., and Reinehr, T. 2005. Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss. J. Clin. Endocrinol. Metab. 90(12): 6386–6391. doi:10.1210/jc. 2005-1357. PMID:16204364.##Moore MS, Dodd CJ, Welsman JR, Armstrong N. Short-term appetite and energy intake following imposed exercise in 9- to 10-year-old girls. Appetite. 2004; 43:127–134. PubMed doi:10.1016/j.appet.2004.02.008.##Dodd CJ, Welsman JR, Armstrong N. Energy intake and appetite following exercise in lean and overweight girls. Appetite. 2008; 51:482–488. PubMed doi:10.1016/j. appet.2008.03.009.##Jobgen W, Meininger CJ, Jobgen SC et al. Dietary L–arginine supplementation reduces white fat gain and enhances skeletal muscl and brown fat masses in diet induced obese rats. JNutr2009a; 139:230–237.##Lucotti P, Setola E, Monti LD et al. Beneficial effects of a long-term oral L -arginine added to a hypocaloric diet and exercise training program in obese, insulin-resistant 2 diabetic patients. Am J Physiol Endocrinol Metab. 2006; 291:E906–E912.##Jobgen W, Fu WJ, Gao H, Li P et al. High fat feeding and dietary L -arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acids. 2009b; 37:187–198.##Flynn NE, Bird JG, Guthrie AS (2009) Glucocorticoid regulation of amino acid and polyamine metabolism in the small intestine. Amino Acids 37:123–129.##Wu G, Collins JK, Perkins-Veazie P et al. Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. J Nutr, 2007b;  137:2680–2685.##Mendez JD, Balderas F. Regulation of hyperglycemia and dyslipidemia by exogenous L -arginine in diabetic rats. Biochimie, 2001; 83:453–458. Fu WJ, Haynes TE, Kohli R et al. Dietary L –arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr, 2005; 135:714–721.##King DE, Mainous AG, Geesey ME (2008) Variation in L –arginine intake follow demographics and lifestyle factors that may impact cardiovascular disease risk. Nutr Res 28:21–24.##Kelly K , Brooks L , Solomon T(2009 )."The glucose-dependent insulin tropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity". Am J Physiol Endocrinol Metab; vol 296 pp: 1269 – 1274.##Day JR, Rossiter HB, Coats EM, Skasick A, Whipp BJ. The maximally attainable VO2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol. 2003; 95(5): 1901-1907. PubMed doi:10.1152/japplphysiol.00024.2003.##WASSERMAN. K. Determinants and detection of anaerobic threshold and consequences of exercise above it.Circulation. 1949; 76(6):29–39.##Howley ET, Bassett, Jr. DR, Welch HG. Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc. 1995; 27(9):1292–01. PubMed doi:10.1249/00005768-199509000-00009.##Jason R, McKnight M, Carey S, Wenjuan S, Jobgen S, Thomas E, Cynthia J, Catherine J, Guoyao W.Beneficial effects of L -arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids, 2010; 39:349–357 DOI 10.1007/s00726-010-0598-z.##Thivel D, Isacco L, Montaurier C, Boirie Y, Duché P, Morio B. The 24-h energy intake of obese adolescents is spontaneously reduced after intensive exercise: a randomized controlled trial in calorimetric chambers. PLoS ONE. 2012; 7:e29840. PubMed doi:10.1371/journal.pone.0029840.##Chearskul, S., Delbridge, E., Shulkes, A., Proietto, J., and Kriketos, A. 2008. Effect of weight loss and ketosis on post prandial cholecystokinin and free fatty acid concentrations. Am. J. Clin. Nutr. 87(5): 1238–1246. PMID:18469245.##Sumithran, P., Prendergast, L.A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., and Proietto, J. 2011. Long-term persistence of hormonal adaptations to weight loss. N. Engl. J. Med. 365(17): 1597–1604. doi:10.1056/NEJMoa1105816. PMID:22029981.##Wagner LP, Mara CL, Thiago Ricardo ST, Babu B, Lila MO, Joao PB, James OH. Effect of Aerobic Exercise on Hunger Feelings and Satiety Regulating Hormones in Obese Teenage Girls. Pediatric Exercise Science, 2014, 26, 463-469.doi:10.1123/ 2013/0200© 2014 Human Kinetics, Inc.##Bailey DP, Smith LR, Chrismas BC, Taylor L, Stensel DJ, Deighton K, et al. Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. Appetite 2015; 89:237-45.##Larson-Meyer DE, Palm S, Bansal A, Austin KJ, Hart AM, Alexander BM. Influence of running and walking on hormonal regulators of appetite in women. J Obes 2012; 2012: 730409.##Terry E, Jone J, Basilio P, Brophy M(2009). "Long-term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin". Obesity vol 17,pp:1189–1195.##Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, Spencer TE, et al. Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 2005;135(4):714-21.##Satterfield M, Wu G. Growth and development of brown adipose tissue: Significance and nutritional regulation. Front Biosci 2011;16:1589-608.##McKnight JR, Satterfield MC, Jobgen WS, Smith SB, Spencer TE, Meininger CJ, et al. Beneficial effects of L-arginine on reducing obesity: Potential mechanisms and important implications for human health. Amino Acids 2010;39(2):349-57.##McGrowdera D, Ragoobirsingh D, Brown P. Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds. J Biosci 2006;31(3):347-54.##
Journal of Applied Exercise Physiology
Volume 14, Issue 28
February 2019
Pages 179-190

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History

  • Receive Date: 04 February 2018
  • Revise Date: 04 April 2018
  • Accept Date: 14 May 2018

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