Effects of Eight Weeks of Endurance and Resistance Training With and Without Supplementation of Garlic Extract on Risk Factors of Coronary Artery Disease in Male Wistar Rats With Metabolic Syndrome

Document Type : Research Paper


1 Department of Exercise Physiology, Faculty of sports sciences, Razi University, Kermanshah, Iran

2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran,


Background and Purpose: this study was conducted to assess and comparison of effects eight-weeks endurance training (ET) and resistance training (RT) and garlic extract supplementation on High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine in male wistar rats with metabolic syndrome.
Methodology: A total of 48 rats with metabolic syndrome (aged 12-wk, weight 331.94±13.67g) were randomly divided into 6 groups of 8 each: endurance training (ET), resistance training (RT), garlic extract supplementation (GE), endurance training with garlic extract supplementation (ET+GE), resistance training with garlic extract supplementation (RT+GE) and control (con). Exercise and dietary interventions for 8 weeks. After familiarization rats with metabolic syndrome, 8-weeks (3 session a week) in a exercise protocol (ET,RT) with and without GE (500 mg.kg-1.day-1).
Results: The results showed that hs-CRP in all groups except Group resistance + garlic is lower than the control group significantly (P˂0.05). Moreover, rang of The hs-CRP in the group of endurance training alone and enduance + garlic is lower than resistance+ garlic (P˂0.05). As well as, range of homocysteine in group of endurance alone, endurance+garlic and resistance garlic is lower compared to control group (P˂0.05). None of intervention was a significant effect on lipoprotein (a) compared to the control group (P>0.05).
Conclusion: Based on the findings of this study can be concluded that endurance training and resistance training with and without garlic extract can be effective in reducing inflammation and coronary artery disease. it would appear that the combination of garlic supplementation with endurance exercise is more helpful than the resistance exercise.




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