Investigation of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during 36 sessions of exercise training

Document Type : Research Paper

Authors

1 Associate professor of Pediatric Gastroenterology, Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Shahid Motahari Hospital, Urmia, Iran.

2 Associate professor of exercise physiology, Faculty of Sport Sciences, Urmia university, Urmia,

3 Sama Technical and Vocational Training College, Islamic Azad University, Urmia Branche, Urmia, Iran

4 Radiologists, Urmia University of Medical Sciences, Shahid Motahari Hospital, Urmia, Iran

5 cardiologist, fellowship electrophysiology and pacemaker, professor assistant, seyyed al shohada hospital, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Background and purpose: Prevalence of overweight and obesity caused by a sedentary lifestyle and poor diet is the problem of health that one of its side effects is Non-Alcoholic Fatty Liver Disease (NAFLD). The aim of this study was to investigate of tissue and blood indices of liver and metabolic syndrome in patients with nonalcoholic fatty liver during a period of exercise training.
Methodology: In this randomized controlled trial, 29 overweight and obese women with liver steatosis with an age range of 22 to 52 years, were randomly divided into two groups: aerobic exercise (n = 13) and control (n = 16). Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate). The control group was sedentary during the same period. Blood samples to determine levels of liver enzymes (SGOT, ALK, SGPT) and serum lipid profile (TG, CHO, HDL, LDL) were collected before and after the test. Data were analyzed using SPSS version 21.
Results:  The results show significant changes of anthropometric parameters (waist circumference) and biochemical variables (ALK and total cholesterol) between the two-experimental and control groups(p≤0/05).
Conclusion: Due to significant changes in a few indicators of the study, 12 weeks of aerobic exercise seems to be at least appropriate way to manage and control the fatty liver and its complications.
 

Keywords


##Jornayvaz FR, Samuel VT, Shulman GI. 2010. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annual review of nutrition. 30:273-290.##Hsieh SD, Muto T, Tsuji H, Arase Y, Murase T. 2010. Clustering of other metabolic risk factors in subjects with metabolic syndrome. Metabolism: clinical and experimental. 59(5):697-702.##Rector RS, Thyfault JP, Wei Y, Ibdah JA. 2008. Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World Journal of Gastroenterol. 14(2):185-192.##Sun B, Karin M: Obesity, inflammation, and liver cancer. 2012. Journal of hepatology. 56(3):704-713.##Nobili V, Carter-Kent C, Feldstein AE. 2011. The role of lifestyle changes in the management of chronic liver disease. BMC medicine. 9:70.##Ucero AC, Sabban B, Benito-Martin A, Carrasco S, Joeken S, Ortiz A. 2013. Laser Therapy in Metabolic Syndrome-related Kidney Injury. Photochemistry and photobiology. 89(4):953-960##Takahashi Y, Fukusato T. 2010. Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology. World J Gastroenterol. 16(42):5280-5285.##Duvnjak M, Tomasic V, Gomercic M, Smircic Duvnjak L, Barsic N, Lerotic I. 2009. Therapy of nonalcoholic fatty liver disease: current status. Journal of Physiology and Pharmacology. 7:57-66.##Reid A. 2006. Nonalcoholic Fatty Liver Disease. In: Feldman M, Friedman L, Lawrence JB (editors) Feldman: Sleisenger & Fordtran's Gastrointe-stinal and Liver Disease 8thed.  Saunders Eisevier:1793-1802.##Straznicky NE, Lambert EA, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Masuo K, Chopra R, Sari CI et al. 2012. The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects. Diabetes, obesity & metabolism. 14(2):139-48.##Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A, Mazzarella R, Longobardo M, Mancini M, Vigorito C et al. 2012. Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes care. 35(7):1429-1435.##Bhat G, Baba CS, Pandey A, Kumari N, Choudhuri G. 2012. Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease. World journal of hepatology. 4(7):209-217.##Barsalani R, Riesco E, Lavoie JM, Dionne IJ. 2013. Effect of exercise training and isoflavones on hepatic steatosis in overweight postmenopausal women. Climacteric. 16(1):88-95##Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, Hawk VH, Muehlbauer MJ, Samsa GP, Nelson RC et al. 2011. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American journal of physiology. 301(5):1033-1039.##Schultes B, Frick J, Ernst B, Stefan N, Fritsche A. 2010. The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women. Experimental and Clinical Endocrinology & Diabetes. 118(10):754-756.##Tokushige K. 2009. Diagnosis and therapy in NASH. Rinsho byori. 57(9):848-853.##Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A, Choudhuri G. 2006. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. Journal of gastroenterology and hepatology. 21(1 Pt 1):191-198.##Schultz A, Mendonca LS, Aguila MB, Mandarim-de-Lacerda CA. 2012. Swimming training beneficial effects in a mice model of nonalcoholic fatty liver disease. Experimental and Toxicologic Pathology. 64(4):273-282.##Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, Day CP, Trenell MI. 2011. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. 60(9):1278-1283.##De Piano A, de Mello MT, Sanches Pde L, da Silva PL, Campos RM, Carnier J, Corgosinho F, Foschini D, Masquio DL, Tock L et al. 2012. Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. European journal of gastroenterology & hepatology. 24(11):1313-1324.##Bozzetto L, Prinster A, Annuzzi G, Costagliola L, Mangione A, Vitelli A, Mazzarella R, Longobardo M, Mancini M, Vigorito C et al. 2012. Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients. Diabetes care. 35(7):1429-1435.##Magkos F.  2010. Exercise and fat accumulation in the human liver. Current opinion in lipidology. 21(6):507-17.##Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, Hawk VH, Muehlbauer MJ, Samsa GP, Nelson RC et al. 2011. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American journal of physiology. 301(5): 1033-1039.##Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. 2012. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology . 55(6):1738-1745.##Yang N, Ginsburg GS, Simmons LA. 2013. Personalized medicine in women's obesity prevention and treatment: implications for research, policy and practice. Obesity Reviews. 14(2):145-1461.##Tchelepi H, Ralls PW, Radin R, Grant E. 2002. Sonography of diffuse liver disease. Journal of Ultrasound Medicin. 21(9):1023-1032.##Yang HJ, Shim SG, Ma BO, Kwak JY. 2016. Association of nonalcoholic fatty liver disease with bone mineral density and serum osteocalcin levels in Korean men. European journal of gastroenterology & hepatology. 28(3):338-344.##Robergs RA, Landwehr R. 2002. The surprising history of the ‘HR max = 220 – age’ equation. Journal of Exercise Physiology online. 5(2): 1-16.##Kelishadi R, Alikhani S, Delavari A, Alaedini F, Safaie A, Hojatzadeh E. 2008. Obesity and associated lifestyle behaviours in Iran: findings from the first national non-communicable disease risk factor surveillance survey. Public health nutrition. 11(03):246-251.##Janghorbani M, Amini M, Willett WC, Gouya MM, Delavari A, Alikhani S, et al. 2007. First nationwide survey of prevalence of overweight, underweight, and abdominal obesity in Iranian adults. Obesity. 15(11):2797-2808.##Paknahad Z, Zeraei-Bidgoli H. 2013. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention. Journal of Isfahan Medical School. 31(252): 1461-1480.##Loomba R, Cortez-Pinto H. Exercise and improvement of NAFLD. 2015. Practical recommendations. Journal of Hepatology. 63: 174–182.##Eslami L, Rahmani-Nia F, Nakhostin-Roohi B. 2014. The effect of 12week vitamin E supplementation and regular physical activity on selected liver enzymes of non-alcoholic fatty liver patients. Sport Physiology. 6(23): 69-82.##Hallsworth, K, Fattakhova, G, Hollingsworth, K.G, Thoma, C, Moore, S, Taylor, R, et al. 2011. Resistance exercise reduces liver fat its mediators in non-alcoholic fatty liver disease independent of weight loss. Hepatology Journal. (60):1278-1283.##Devries MC, Samjoo IA, Hamadeh MJ, Tarnopolsky MA. 2008. Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity (Silver Spring). 16(10):2281-2288.##Bahari S, Faramarzi M, Azamian Jazi A, Cheragh Cheshm M. 2014. The Effect of 8 Week Resistance Training on Resting Level of Liver Inflammatory Markers and Insulin Resistance of Type 2 Diabetic Women. ARMAGHAN DANESH. 19(5): 450-461.##Barzegarzadeh-Zarandi H, Dabidy-Roshan V. 2012. Changes in some liver enzymes and blood lipid level following interval and continuous regular aerobic training in old rats. Journal of Shahrekord  of Medical Science. 14(5): 13-23##Angulo P. 2002. Nonalcoholic fatty liver disease. The New England Journal of Medicine. 346 (16): 1221–1231.##