Background & purpose:Multiple Sclerosis (MS) is the most prevalent disease of the central nerve system. This disease has negative effects on physical and mental health. Cytokines and Free Radicals play an important role in the pathogenesis of Multiple Sclerosis and they are the major targets of therapeutic interventions. Regular exercise reduces functional loss associated with multiple sclerosis. However, the impact of exercise on cytokines and free radicals associated with disease activity is remained relatively unexplored. The aim of this study was to examine the effects of 8 weeks Aerobic Exercise Training (AET) on IL-10 and NO levels, fatigue and quality of life in female patients with MS. Methodology:participants of the study were included 30 females with MS disease with average age of 30.11±6.97 and EDSS less than 3. They were randomly divided into control (n=15) and training (n=15) groups. The training group performed AET program, 3 days a week for 8 weeks. Results were analyzed by covariance analysis test through continual measures (ANCOVA), covariance and independent T-test at p≤0.05 significant level. Results: The results showed that, IL-10 increased significantly in the exercise group and NO decreased significantly in the exercise group compare to control group. Also, Fatigue decreased significantly in exercise group compared to control group, following eight weeks of AET,. and quality of life increased significantly in exercise group versus control group following eight weeks of AET . Conclusion:The results suggested that aerobic exercise training with low to moderate intensity (i.e., %40 to %70 of VO2max), according MS patientʼs ability so that, It does not exacerbate the symptoms of the disease, including heat sensitivity and fatigue, can be beneficial for MS patients through improving fatigue and quality of life and increasing in Anti Inflammatory cytokines like IL-10 and reduction in free radicals like NO.
Hooshmandi, Z., & Koushki -Jahromi, M. (2017). Effect of Aerobic Exercise on Anti Inflammatory Cytokine)Interlukin- 10), Free Radical)Nitric Oxide), Fatigue and Quality of Life in Multiple Sclerosis Patients. Journal of Applied Exercise Physiology, 13(25), 51-62. doi: 10.22080/jaep.2017.1587
MLA
Zeinab Hooshmandi; Maryam Koushki -Jahromi. "Effect of Aerobic Exercise on Anti Inflammatory Cytokine)Interlukin- 10), Free Radical)Nitric Oxide), Fatigue and Quality of Life in Multiple Sclerosis Patients". Journal of Applied Exercise Physiology, 13, 25, 2017, 51-62. doi: 10.22080/jaep.2017.1587
HARVARD
Hooshmandi, Z., Koushki -Jahromi, M. (2017). 'Effect of Aerobic Exercise on Anti Inflammatory Cytokine)Interlukin- 10), Free Radical)Nitric Oxide), Fatigue and Quality of Life in Multiple Sclerosis Patients', Journal of Applied Exercise Physiology, 13(25), pp. 51-62. doi: 10.22080/jaep.2017.1587
VANCOUVER
Hooshmandi, Z., Koushki -Jahromi, M. Effect of Aerobic Exercise on Anti Inflammatory Cytokine)Interlukin- 10), Free Radical)Nitric Oxide), Fatigue and Quality of Life in Multiple Sclerosis Patients. Journal of Applied Exercise Physiology, 2017; 13(25): 51-62. doi: 10.22080/jaep.2017.1587
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