پاسخ سطح سرمی عامل القایی هایپوکسی یک آلفا، فاکتور رشد اندوتلیال عروق و در صد اشباع مویرگی به یک جلسه تمرین شنای تناوبی زیر آبی (آپنه ای) در مردان جوان

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزش، ، دانشگاه بیرجند، بیرجند، ایران (نویسنده مسئول)،

2 کارشناس ارشد فیزیولوژی ورزش، دانشگاه بیرجند، بیرجند، ایران

3 دانشجوی دکتری فیزیولوژی ورزش، دانشگاه بیرجند، بیرجند، ایران

چکیده

سابقه و هدف: سطوح سرمی عامل القایی هایپوکسی یک آلفا (HIF-1α) و عامل رشد اندوتلیال عروق (VEGF)  به عنوان فاکتورهای مهم در فرایند رگ زایی، با فعالیت ورزشی تغییر مى کنند. هدف از تحقیق حاضر، بررسی پاسخ سطوح سرمی HIF-1α، VEGF و درصد اشباع اکسیژن مویرگی محیطی (SpO2) متعاقب 1 جلسه تمرین شنای زیر آبی در مردان جوان بود.
مواد و روش ها: ده شناگر مرد (میانگین سن 26/2± 30/23 سال و شاخص توده بدنی 91/3± 80/23 کیلوگرم بر متر مربع)، داوطلبانه در این تحقیق شرکت کردند. تمرین شامل 20 متر شنای زیر آبی بود که 10 بار تکرار شد و بین هر 2 تکرار نیز 1 دقیقه استراحت در نظر گرفته شده بود. نمونه‌گیری خون، قبل، بلافاصله و 2 ساعت پس از اجرای تمرین انجام شد. میزان SpO2 قبل، بلافاصله پس از هر تکرار و 1 دقیقه بعد از اتمام تمرین اندازه‌‌گیری شد. داده‌ها با استفاده از آزمون آنالیز واریانس با اندازه‌گیری‌های مکرر و آزمون تعقیبی بونفرونی در سطح معناداری 05/0 P
یافته‌ها: یک جلسه تمرین شنای زیر آبی، موجب افزایش معنادارVEGF  سرم بلافاصله پس از تمرین شد (02/0P=) و 2 ساعت پس از تمرین به حدود سطح پایه بازگشت (67/0P=). سطح سرمیHIF-1α  بلافاصله پس از تمرین تغییر معناداری نداشت (99/0P=)، اما 2 ساعت پس از تمرین کاهش معناداری داشت (01/0P=). علاوه بر آن، تغییر معناداری در میزان SpO2 در هر 2 زمان پس از تمرین مشاهده نشد (05/0P=).  
نتیجه گیری: به نظر می رسد تمرینات شنای زیر آبی، با کاهش سطح سرمی HIF-1α  و افزایش سطح سرمی VEGF می تواند به عنوان یک عامل در شروع فرایندهای رگ زایی مشارکت داشته باشد و در جهت افزایش چگالی مویرگی در ورزشکاران مورد مطالعه قرار گیرد.

کلیدواژه‌ها


عنوان مقاله [English]

The response of serum levels of hypoxia inducible factor –1α, vascular endothelial growth factor and peripheral capillary oxygen saturation to one session of underwater swimming training (Apnea) in young men

نویسندگان [English]

  • . . 1
  • . . 2
  • . . 3
چکیده [English]

Background and aim: serum levels of hypoxia induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) as important factors in the process of angiogenesis, are change during exercise. The purpose of this study was assessment of the responsive serum levels of HIF-1α and VEGF and peripheral capillary oxygen saturation (SpO2), following one session underwater swimming in young men.
Methods: Ten male swimmers (mean age 23.3±2.26 years and BMI 23.8±3.91 kg/m²), voluntarily participated in this study. The exercise was repeated 10 times to 20 meters underwater swimming with a one minute rest between each repetition. Blood sampling, immediately and two hours after the exercise was done. SpO2 levels before, immediately after and one hour after the end of each workout was measured. The obtained data analyzed using analysis of variance with repeated measures and the Bonferroni post hoc test, with a significant level of P<0.05.
Results: A training, leading to a significant increase in serum level of VEGF immediately after exercise (P=0.02) and two hours after exercise returned to nearly baseline (P=0.67). Serum level of HIF-1α not significantly change after training (P=0.99), but the two hours after exercise had a significant reduction (P=0.01). In addition, no significant change was observed in the SpO2 in both time after exercise (P=0.05).
Conclusion: It seems that swimming underwater, with a reduction in serum levels of HIF-1α and elevation of serum VEGF, can contribute as a factor to be involved in the angiogenesis process and considered to increase capillary density in athletes.

کلیدواژه‌ها [English]

  • saturation
  • Swimming
  • Apnea
  • Hypoxia inducible factor –1α
  • Vascular Endothelial Growth Factor
  • Peripheral capillary oxygen
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